MetaCyc Pathway: superpathway of guanosine nucleotides de novo biosynthesis II in Rahnella sp. WP5

Add experiment(s):


IMP dehydrogenase:
IMP + NAD+ + H2O→XMP + NADH + H+ (EC 1.1.1.205)
EX31_RS20450
GMP synthase (glutamine-hydrolyzing):
XMP + ATP + L-glutamine + H2O→GMP + AMP + L-glutamate + diphosphate + 2 H+ (EC 6.3.5.2)
EX31_RS08365
EX31_RS20445
Guanylate kinase:
GMP + ATP→GDP + ADP (EC 2.7.4.8)
EX31_RS08445
EX31_RS15800
Nucleoside-diphosphate kinase:
GDP + ATP→GTP + ADP (EC 2.7.4.6)
EX31_RS20530
EX31_RS22535
Ribonucleoside-diphosphate reductase (in reverse):
GDP + a reduced thioredoxin→dGDP + an oxidized thioredoxin + H2O (EC 1.17.4.1)
EX31_RS13570
EX31_RS13575
EX31_RS13580
EX31_RS19305
EX31_RS19310
Ribonucleoside-diphosphate reductase (in reverse):
GDP + a reduced NrdH glutaredoxin-like protein→dGDP + an oxidized NrdH glutaredoxin-like protein + H2O (EC 1.17.4.1)
EX31_RS13575
EX31_RS13580
EX31_RS19305
EX31_RS19310
Nucleoside-diphosphate kinase:
dGDP + ATP→dGTP + ADP (EC 2.7.4.6)
EX31_RS20530
EX31_RS22535
GTP + formate + H+→dGTP + CO2 + H2O (EC 1.1.98.6)
EX31_RS08395

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information