MetaCyc Pathway: L-lysine biosynthesis VI in Rahnella sp. WP5

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Aspartate kinase:
L-aspartate + ATP→L-aspartyl-4-phosphate + ADP
(EC 2.7.2.4)
EX31_RS03945
EX31_RS11810
EX31_RS14210
Aspartate-semialdehyde dehydrogenase (in reverse):
L-aspartyl-4-phosphate + NADPH + H+→L-aspartate 4-semialdehyde + NADP+ + phosphate
(EC 1.2.1.11)
EX31_RS05030
EX31_RS19605
L-aspartate 4-semialdehyde + pyruvate→(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H+ + H2O (EC 4.3.3.7)
EX31_RS01400
EX31_RS02595
EX31_RS02825
EX31_RS13735
EX31_RS17515
EX31_RS22740
(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H + H+→(S)-2,3,4,5-tetrahydrodipicolinate + NAD(P)+ + H2O (EC 1.17.1.8)
EX31_RS03840
LL-diaminopimelate aminotransferase (in reverse):
(S)-2,3,4,5-tetrahydrodipicolinate + L-glutamate + H+ + H2O→L,L-diaminopimelate + 2-oxoglutarate
(EC 2.6.1.83)
No genes
Diaminopimelate epimerase:
L,L-diaminopimelate→meso-diaminopimelate
(EC 5.1.1.7)
EX31_RS10160
EX31_RS10630
EX31_RS15155
Diaminopimelate decarboxylase:
meso-diaminopimelate + H+→L-lysine + CO2
(EC 4.1.1.20)
EX31_RS02420
EX31_RS13275

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information