MetaCyc Pathway: superpathway of hexuronide and hexuronate degradation in Rahnella sp. WP5

MetaCyc Pathway: superpathway of hexuronide and hexuronate degradation in Rahnella sp. WP5

Beta-glucuronidase:
a β-D-glucuronide + H₂O→D-glucopyranuronate + an alcohol (EC 3.2.1.31)

No genes

Glucuronate isomerase:
aldehydo-D-galacturonate→D-tagaturonate (EC 5.3.1.12)

Tagaturonate reductase (in reverse):
D-tagaturonate + NADH + H⁺→D-altronate + NAD⁺ (EC 1.1.1.58)

D-glucopyranuronate→aldehydo-D-glucuronate (spontaneous)

No genes

Altronate dehydratase:
D-altronate→2-dehydro-3-deoxy-D-gluconate + H₂O (EC 4.2.1.7)

Glucuronate isomerase:
aldehydo-D-glucuronate→D-fructuronate (EC 5.3.1.12)

Fructuronate reductase (in reverse):
D-fructuronate + NADH + H⁺→D-mannonate + NAD⁺ (EC 1.1.1.57)

Mannonate dehydratase:
D-mannonate→2-dehydro-3-deoxy-D-gluconate + H₂O (EC 4.2.1.8)

2-dehydro-3-deoxy-D-gluconate + ATP→2-dehydro-3-deoxy-D-gluconate 6-phosphate + ADP + H⁺ (EC 2.7.1.178; 2.7.1.45)

2-dehydro-3-deoxy-phosphogluconate aldolase:
2-dehydro-3-deoxy-D-gluconate 6-phosphate→D-glyceraldehyde 3-phosphate + pyruvate (EC 4.1.2.14; 4.1.2.55)

Links:

Pathway details at MetaCyc
Fitness data for 9 genes
Select organism:
All MetaCyc pathways for Rahnella sp. WP5

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information