MetaCyc Pathway: hopanoid biosynthesis (bacteria) in Rhodopseudomonas palustris CGA009

Add experiment(s):


2 (2E,6E)-farnesyl diphosphate→presqualene diphosphate + diphosphate (EC 2.5.1.103; 2.5.1.21; 2.5.1.96)
TX73_019380
presqualene diphosphate + H2O→hydroxysqualene + diphosphate (EC 4.2.3.156)
TX73_019385
hydroxysqualene + FADH2→squalene + FAD + H+ + H2O (EC 1.17.8.1)
TX73_019375
Squalene--hopene cyclase:
squalene→hop-22(29)-ene (EC 5.4.99.17)
TX73_019370
squalene + H2O→tetrahymanol (EC 4.2.1.123)
No genes
squalene + H2O→hopan-22-ol (EC 4.2.1.129)
TX73_019370
hop-22(29)-ene + a reduced two electron carrier + S-adenosyl-L-methionine→adenosyl hopane + an oxidized electron carrier + L-methionine + H+
TX73_019345
tetrahymanol + methylcob(III)alamin + S-adenosyl-L-methionine→2-methyltetrahymanol + 5'-deoxyadenosine + cob(III)alamin + L-methionine
TX73_019410
hopan-22-ol + methylcob(III)alamin + S-adenosyl-L-methionine→2-methyldiplopterol + 5'-deoxyadenosine + cob(III)alamin + L-methionine
TX73_019410
adenosyl hopane + H2O→ribosyl hopane + adenine
TX73_019365
ribosyl hopane→formyl hopane (spontaneous)
No genes
formyl hopane + a reduced two electron carrier→bacteriohopanetetrol + an oxidized electron carrier
No genes
formyl hopane + L-glutamate→aminobacteriohopanetriol + 2-oxoglutarate
TX73_019330
bacteriohopanetetrol + methylcob(III)alamin + S-adenosyl-L-methionine→2-methylbacteriohopanetetrol + 5'-deoxyadenosine + cob(III)alamin + L-methionine
TX73_019410

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information