MetaCyc Pathway: 8-amino-7-oxononanoate biosynthesis I in Rhodopseudomonas palustris CGA009

Add experiment(s):


a malonyl-[acp] + S-adenosyl-L-methionine→a malonyl-[acp] methyl ester + S-adenosyl-L-homocysteine (EC 2.1.1.197)
No genes
Beta-ketoacyl-acyl-carrier-protein synthase II:
a malonyl-[acp] + a malonyl-[acp] methyl ester + H+→a 3-oxoglutaryl-[acp] methyl ester + a soluble [acyl-carrier protein] + CO2 (EC 2.3.1.179; 2.3.1.41)
TX73_002215
TX73_010405
TX73_010410
TX73_015890
3-oxoacyl-[acyl-carrier-protein] reductase (in reverse):
a 3-oxoglutaryl-[acp] methyl ester + NADPH + H+→a (3R)-3-hydroxyglutaryl-[acp] methyl ester + NADP+ (EC 1.1.1.100)
TX73_000560
TX73_002485
TX73_003390
TX73_004045
TX73_004610
TX73_004615
TX73_008650
TX73_008655
TX73_008935
TX73_011140
TX73_012495
TX73_015900
TX73_016995
TX73_017080
TX73_017465
TX73_017980
TX73_018405
TX73_018410
TX73_020990
TX73_023875
TX73_024180
3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase:
a (3R)-3-hydroxyglutaryl-[acp] methyl ester→a (2E)-enoylglutaryl-[acp] methyl ester + H2O (EC 4.2.1.59)
TX73_002210
TX73_010415
TX73_015090
Enoyl-[acyl-carrier-protein] reductase (NADH) (in reverse):
a (2E)-enoylglutaryl-[acp] methyl ester + NADH + H+→a glutaryl-[acp] methyl ester + NAD+ (EC 1.3.1.9)
TX73_002220
TX73_006160
TX73_010005
TX73_011140
TX73_016095
TX73_023730
Beta-ketoacyl-acyl-carrier-protein synthase II:
a glutaryl-[acp] methyl ester + a malonyl-[acp] + H+→a 3-oxopimeloyl-[acp] methyl ester + a soluble [acyl-carrier protein] + CO2 (EC 2.3.1.179; 2.3.1.41)
TX73_002215
TX73_010405
TX73_010410
TX73_015890
3-oxoacyl-[acyl-carrier-protein] reductase (in reverse):
a 3-oxopimeloyl-[acp] methyl ester + NADPH + H+→a (3R)-3-hydroxypimeloyl-[acp] methyl ester + NADP+ (EC 1.1.1.100)
TX73_000560
TX73_002485
TX73_003390
TX73_004045
TX73_004610
TX73_004615
TX73_008650
TX73_008655
TX73_008935
TX73_011140
TX73_012495
TX73_015900
TX73_016995
TX73_017080
TX73_017465
TX73_017980
TX73_018405
TX73_018410
TX73_020990
TX73_023875
TX73_024180
3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase:
a (3R)-3-hydroxypimeloyl-[acp] methyl ester→a (2E)-enoylpimeloyl-[acp] methyl ester + H2O (EC 4.2.1.59)
TX73_002210
TX73_010415
TX73_015090
Enoyl-[acyl-carrier-protein] reductase (NADH) (in reverse):
a (2E)-enoylpimeloyl-[acp] methyl ester + NADH + H+→a pimeloyl-[acp] methyl ester + NAD+ (EC 1.3.1.9)
TX73_002220
TX73_006160
TX73_010005
TX73_011140
TX73_016095
TX73_023730
a pimeloyl-[acp] methyl ester + H2O→a pimeloyl-[acp] + methanol + H+ (EC 3.1.1.85)
No genes
8-amino-7-oxononanoate synthase:
a pimeloyl-[acp] + L-alanine + H+→(8S)-8-amino-7-oxononanoate + a soluble [acyl-carrier protein] + CO2 (EC 2.3.1.47)
TX73_015415

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information