MetaCyc Pathway: flavin biosynthesis I (bacteria and plants) in Pseudomonas sp. BP01

Add experiment(s):


3,4-dihydroxy-2-butanone-4-phosphate synthase:
D-ribulose 5-phosphate→1-deoxy-L-glycero-tetrulose 4-phosphate + formate + H+ (EC 4.1.99.12)
JOY50_RS04730 (ribBA)
JOY50_RS20050 (ribB)
JOY50_RS20085 (ribA)
JOY50_RS20115 (ribBA)
GTP cyclohydrolase II:
GTP + 4 H2O→2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + formate + 3 H+ + 2 phosphate (EC 3.5.4.25)
JOY50_RS04730 (ribBA)
JOY50_RS20085 (ribA)
JOY50_RS20115 (ribBA)
Diaminohydroxyphosphoribosylaminopyrimidine deaminase:
2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + H+ + H2O→5-amino-6-(5-phospho-D-ribosylamino)uracil + ammonium (EC 3.5.4.26)
JOY50_RS20125 (ribD)
5-amino-6-(5-phosphoribosylamino)uracil reductase (in reverse):
5-amino-6-(5-phospho-D-ribosylamino)uracil + NADPH + H+→5-amino-6-(5-phospho-D-ribitylamino)uracil + NADP+ (EC 1.1.1.193)
JOY50_RS20125 (ribD)
5-amino-6-(5-phospho-D-ribitylamino)uracil + H2O→5-amino-6-(D-ribitylamino)uracil + phosphate (EC 3.1.3.104)
No genes
5-amino-6-(D-ribitylamino)uracil + 1-deoxy-L-glycero-tetrulose 4-phosphate→6,7-dimethyl-8-(1-D-ribityl)lumazine + H+ + phosphate + 2 H2O (EC 2.5.1.78)
JOY50_RS20110 (ribE)
Riboflavin synthase:
2 6,7-dimethyl-8-(1-D-ribityl)lumazine + H+→5-amino-6-(D-ribitylamino)uracil + riboflavin (EC 2.5.1.9)
JOY50_RS20120
JOY50_RS27330
Riboflavin kinase:
riboflavin + ATP→FMN + ADP + H+ (EC 2.7.1.26)
JOY50_RS27065 (ribF)
FAD synthetase:
FMN + ATP + H+→FAD + diphosphate (EC 2.7.7.2)
JOY50_RS27065 (ribF)

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information