MetaCyc Pathway: colanic acid building blocks biosynthesis in Parabacteroides merdae CL09T00C40

Glucose-6-phosphate isomerase: α-D-glucose 6-phosphate→β-D-fructofuranose 6-phosphate (EC 5.3.1.9)

HMPREF1078_RS10075

Phosphoglucomutase (in reverse): D-glucopyranose 6-phosphate→α-D-glucopyranose 1-phosphate (EC 5.4.2.2)

HMPREF1078_RS00820

HMPREF1078_RS13980

UTP-monosaccharide-1-phosphate uridylyltransferase: α-D-glucopyranose 1-phosphate + H+ + UTP→UDP-α-D-glucose + diphosphate (EC 2.7.7.64; 2.7.7.9)

No genes

Mannose-6-phosphate isomerase (in reverse): β-D-fructofuranose 6-phosphate→D-mannopyranose 6-phosphate (EC 5.3.1.8)

HMPREF1078_RS09880

Phosphomannomutase (in reverse): D-mannopyranose 6-phosphate→α-D-mannose 1-phosphate (EC 5.4.2.8)

HMPREF1078_RS00820

HMPREF1078_RS13980

UDP-glucose 4-epimerase: UDP-α-D-glucose→UDP-α-D-galactose (EC 5.1.3.2)

HMPREF1078_RS15420

UDP-glucose 6-dehydrogenase: UDP-α-D-glucose + 2 NAD+ + H2O→UDP-α-D-glucuronate + 2 NADH + 3 H+ (EC 1.1.1.22)

HMPREF1078_RS01515

HMPREF1078_RS02670

HMPREF1078_RS07195

HMPREF1078_RS17435

HMPREF1078_RS17475

Mannose-1-phosphate guanylyltransferase: α-D-mannose 1-phosphate + GTP + H+→GDP-α-D-mannose + diphosphate (EC 2.7.7.13)

No genes

GDP-mannose 4,6-dehydratase: GDP-α-D-mannose→GDP-4-dehydro-α-D-rhamnose + H2O (EC 4.2.1.47)

HMPREF1078_RS00185

HMPREF1078_RS03855

GDP-L-fucose synthase: GDP-4-dehydro-α-D-rhamnose→GDP-4-dehydro-6-deoxy-β-L-galactose (EC 1.1.1.271)

HMPREF1078_RS00180

HMPREF1078_RS03850

GDP-L-fucose synthase (in reverse): GDP-4-dehydro-6-deoxy-β-L-galactose + NADPH + H+→GDP-β-L-fucose + NADP+ (EC 1.1.1.271)

HMPREF1078_RS00180

HMPREF1078_RS03850

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information