MetaCyc Pathway: flavin biosynthesis I (bacteria and plants) in Pedobacter sp. GW460-11-11-14-LB5

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3,4-dihydroxy-2-butanone-4-phosphate synthase:
D-ribulose 5-phosphate→1-deoxy-L-glycero-tetrulose 4-phosphate + formate + H+ (EC 4.1.99.12)
CA265_RS00580
GTP cyclohydrolase II:
GTP + 4 H2O→2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + formate + 3 H+ + 2 phosphate (EC 3.5.4.25)
CA265_RS00580
Diaminohydroxyphosphoribosylaminopyrimidine deaminase:
2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + H+ + H2O→5-amino-6-(5-phospho-D-ribosylamino)uracil + ammonium (EC 3.5.4.26)
CA265_RS09530
5-amino-6-(5-phosphoribosylamino)uracil reductase (in reverse):
5-amino-6-(5-phospho-D-ribosylamino)uracil + NADPH + H+→5-amino-6-(5-phospho-D-ribitylamino)uracil + NADP+ (EC 1.1.1.193)
CA265_RS09530
5-amino-6-(5-phospho-D-ribitylamino)uracil + H2O→5-amino-6-(D-ribitylamino)uracil + phosphate (EC 3.1.3.104)
No genes
5-amino-6-(D-ribitylamino)uracil + 1-deoxy-L-glycero-tetrulose 4-phosphate→6,7-dimethyl-8-(1-D-ribityl)lumazine + H+ + phosphate + 2 H2O (EC 2.5.1.78)
CA265_RS17135
Riboflavin synthase:
2 6,7-dimethyl-8-(1-D-ribityl)lumazine + H+→5-amino-6-(D-ribitylamino)uracil + riboflavin (EC 2.5.1.9)
CA265_RS02220
Riboflavin kinase:
riboflavin + ATP→FMN + ADP + H+ (EC 2.7.1.26)
CA265_RS16165
FAD synthetase:
FMN + ATP + H+→FAD + diphosphate (EC 2.7.7.2)
CA265_RS16165

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information