MetaCyc Pathway: L-leucine degradation IV (reductive Stickland reaction) in Pedobacter sp. GW460-11-11-14-LB5

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Branched-chain-amino-acid transaminase:
L-leucine + 2-oxoglutarate→4-methyl-2-oxopentanoate + L-glutamate (EC 2.6.1.42; 2.6.1.6)
CA265_RS14410
CA265_RS15785
CA265_RS22650
4-methyl-2-oxopentanoate + NADH + H+→(R)-2-hydroxy-4-methylpentanoate + NAD+ (EC 1.1.1.345)
No genes
(R)-2-hydroxy-4-methylpentanoate + 4-methylpentanoyl-CoA→(R)-2-hydroxy-4-methylpentanoyl-CoA + 4-methylpentanoate (EC 2.8.3.24)
No genes
(R)-2-hydroxy-4-methylpentanoyl-CoA→4-methylpent-2-enoyl-CoA + H2O (EC 4.2.1.157)
No genes
Trans-2-enoyl-CoA reductase (NAD(+)) (in reverse):
4-methylpent-2-enoyl-CoA + NADH + H+→4-methylpentanoyl-CoA + NAD+ (EC 1.3.1.44)
CA265_RS24060

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information