MetaCyc Pathway: superpathway of sulfate assimilation and cysteine biosynthesis in Shewanella loihica PV-4

Phosphoglycerate dehydrogenase: 3-phospho-D-glycerate + NAD+→3-phosphooxypyruvate + NADH + H+ (EC 1.1.1.95)

Shew_0553

Shew_0887

Shew_3196

Sulfate adenylyltransferase: sulfate + ATP + H+→adenosine 5'-phosphosulfate + diphosphate (EC 2.7.7.4)

Shew_1422

Shew_1423

Adenylyl-sulfate kinase: adenosine 5'-phosphosulfate + ATP→3'-phosphoadenylyl-sulfate + ADP + H+ (EC 2.7.1.25)

Shew_1425

Phosphoserine transaminase (in reverse): 3-phosphooxypyruvate + L-glutamate→O-phospho-L-serine + 2-oxoglutarate (EC 2.6.1.52)

Shew_1950

Phosphoadenylyl-sulfate reductase (thioredoxin) (in reverse): 3'-phosphoadenylyl-sulfate + a reduced thioredoxin→sulfite + adenosine 3',5'-bisphosphate + an oxidized thioredoxin + 2 H+ (EC 1.8.4.8)

Shew_0667

Phosphoserine phosphatase: O-phospho-L-serine + H2O→L-serine + phosphate (EC 3.1.3.3)

Shew_2810

Serine O-acetyltransferase: L-serine + acetyl-CoA→O-acetyl-L-serine + coenzyme A (EC 2.3.1.30)

Shew_2319

Sulfite reductase (NADPH) (in reverse): sulfite + 3 NADPH + 5 H+→hydrogen sulfide + 3 NADP+ + 3 H2O (EC 1.8.1.2)

Shew_0665

Shew_0666

Cysteine synthase: O-acetyl-L-serine + hydrogen sulfide→L-cysteine + acetate + H+ (EC 2.5.1.47)

Shew_2060

Shew_2382

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information