MetaCyc Pathway: 8-amino-7-oxononanoate biosynthesis IV in Shewanella loihica PV-4

MetaCyc Pathway: 8-amino-7-oxononanoate biosynthesis IV in Shewanella loihica PV-4

glutaryl-CoA + a malonyl-[acp] + H⁺→a 3-oxopimeloyl-[acp] + CO₂ + coenzyme A

No genes

3-oxoacyl-[acyl-carrier-protein] reductase (in reverse):
a 3-oxopimeloyl-[acp] + NADPH + H⁺→a (3R)-3-hydroxypimeloyl-[acp] + NADP⁺ (EC 1.1.1.100)

Shew_1673 (fabG)

Shew_3525 (fabG)

3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase:
a (3R)-3-hydroxypimeloyl-[acp]→a 2-enoyl-pimeloyl-[acp] + H₂O (EC 4.2.1.59)

Enoyl-[acyl-carrier-protein] reductase (NADH) (in reverse):
a 2-enoyl-pimeloyl-[acp] + NADH + H⁺→a pimeloyl-[acp] + NAD⁺ (EC 1.3.1.9)

8-amino-7-oxononanoate synthase:
a pimeloyl-[acp] + L-alanine + H⁺→(8S)-8-amino-7-oxononanoate + a soluble [acyl-carrier protein] + CO₂ (EC 2.3.1.47)

Links:

Pathway details at MetaCyc
Fitness data for 11 genes
Select organism:
All MetaCyc pathways for Shewanella loihica PV-4

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information