MetaCyc Pathway: peptidoglycan biosynthesis I (meso-diaminopimelate containing) in Shewanella loihica PV-4

Add experiment(s):


D-alanine--D-alanine ligase:
2 D-alanine + ATP→D-alanyl-D-alanine + ADP + H+ + phosphate (EC 6.3.2.4)
Shew_2133 (ddl)
Glutamate racemase:
L-glutamate→D-glutamate (EC 5.1.1.3)
Shew_0139
UDP-N-acetylglucosamine 1-carboxyvinyltransferase:
UDP-N-acetyl-α-D-glucosamine + phosphoenolpyruvate→UDP-N-acetyl-α-D-glucosamine-enolpyruvate + phosphate (EC 2.5.1.7)
Shew_3298
UDP-N-acetyl-α-D-glucosamine-enolpyruvate + NADPH + H+→UDP-N-acetyl-α-D-muramate + NADP+ (EC 1.3.1.98)
Shew_0141
UDP-N-acetylmuramate--L-alanine ligase:
UDP-N-acetyl-α-D-muramate + L-alanine + ATP→UDP-N-acetyl-α-D-muramoyl-L-alanine + ADP + H+ + phosphate (EC 6.3.2.8)
Shew_3452
UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase:
UDP-N-acetyl-α-D-muramoyl-L-alanine + D-glutamate + ATP→UDP-N-acetyl-α-D-muramoyl-L-alanyl-D-glutamate + ADP + H+ + phosphate (EC 6.3.2.9)
Shew_3455
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase:
UDP-N-acetyl-α-D-muramoyl-L-alanyl-D-glutamate + meso-diaminopimelate + ATP→UDP-MurNAc-L-Ala-γ-D-Glu-meso-DAP + ADP + H+ + phosphate (EC 6.3.2.13)
Shew_3458
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase:
D-alanyl-D-alanine + UDP-MurNAc-L-Ala-γ-D-Glu-meso-DAP + ATP→UDP-MurNAc-L-Ala-γ-D-Glu-meso-DAP-D-Ala-D-Ala + ADP + H+ + phosphate (EC 6.3.2.10)
Shew_3457
Phospho-N-acetylmuramoyl-pentapeptide-transferase:
UDP-MurNAc-L-Ala-γ-D-Glu-meso-DAP-D-Ala-D-Ala + di-trans,octa-cis-undecaprenyl phosphate→Und-PP-MurNAc-L-Ala-γ-D-Glu-meso-DAP-D-Ala-D-Ala + UMP (EC 2.7.8.13)
Shew_3456
acetylglucosaminyltransferase:
Und-PP-MurNAc-L-Ala-γ-D-Glu-meso-DAP-D-Ala-D-Ala + UDP-N-acetyl-α-D-glucosamine→Und-PP-[β-D-GlcNAc-(1→4)]-MurNAc-L-Ala-γ-D-Glu-meso-DAP-D-Ala-D-Ala + H+ + UDP (EC 2.4.1.227)
Shew_3453
Und-PP-[β-D-GlcNAc-(1→4)]-MurNAc-L-Ala-γ-D-Glu-meso-DAP-D-Ala-D-Ala[in] + H+[out]→Und-PP-[β-D-GlcNAc-(1→4)]-MurNAc-L-Ala-γ-D-Glu-meso-DAP-D-Ala-D-Ala[out] + H+[in]
No genes
Peptidoglycan glycosyltransferase:
Und-PP-[β-D-GlcNAc-(1→4)]-MurNAc-L-Ala-γ-D-Glu-meso-DAP-D-Ala-D-Ala + a nascent peptidoglycan with (L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine) pentapeptide→a nascent peptidoglycan with (L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine) pentapeptide + di-trans,octa-cis-undecaprenyl diphosphate (EC 2.4.1.129)
Shew_0207
Shew_2936
Shew_3123
Shew_3454
Shew_3459

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information