MetaCyc Pathway: superpathway of aromatic amino acid biosynthesis in Shewanella loihica PV-4

MetaCyc Pathway: superpathway of aromatic amino acid biosynthesis in Shewanella loihica PV-4

3-deoxy-7-phosphoheptulonate synthase:
D-erythrose 4-phosphate + phosphoenolpyruvate + H₂O→3-deoxy-D-arabino-heptulosonate 7-phosphate + phosphate (EC 2.5.1.54)

3-dehydroquinate synthase:
3-deoxy-D-arabino-heptulosonate 7-phosphate→3-dehydroquinate + phosphate (EC 4.2.3.4)

3-dehydroquinate dehydratase:
3-dehydroquinate→3-dehydroshikimate + H₂O (EC 4.2.1.10)

Shikimate dehydrogenase (in reverse):
3-dehydroshikimate + NADPH + H⁺→shikimate + NADP⁺ (EC 1.1.1.25)

Shikimate kinase:
shikimate + ATP→shikimate 3-phosphate + ADP + H⁺ (EC 2.7.1.71)

3-phosphoshikimate 1-carboxyvinyltransferase:
shikimate 3-phosphate + phosphoenolpyruvate→5-enolpyruvoyl-shikimate 3-phosphate + phosphate (EC 2.5.1.19)

Chorismate synthase:
5-enolpyruvoyl-shikimate 3-phosphate→chorismate + phosphate (EC 4.2.3.5)

Anthranilate synthase:
chorismate + L-glutamine→anthranilate + L-glutamate + H⁺ + pyruvate (EC 4.1.3.27)

Chorismate mutase:
chorismate→prephenate (EC 5.4.99.5)

Shew_1068 (tyrA)

Prephenate dehydratase:
prephenate + H⁺→3-phenyl-2-oxopropanoate + CO₂ + H₂O (EC 4.2.1.51)

Prephenate dehydrogenase:
prephenate + NAD⁺→3-(4-hydroxyphenyl)pyruvate + CO₂ + NADH (EC 1.3.1.12)

Shew_1068 (tyrA)

Anthranilate phosphoribosyltransferase (in reverse):
anthranilate + 5-phospho-α-D-ribose 1-diphosphate→N-(5-phosphoribosyl)-anthranilate + diphosphate (EC 2.4.2.18)

Phosphoribosylanthranilate isomerase:
N-(5-phosphoribosyl)-anthranilate→1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate (EC 5.3.1.24)

Aspartate transaminase (in reverse):
3-phenyl-2-oxopropanoate + L-glutamate→L-phenylalanine + 2-oxoglutarate (EC 2.6.1.1; 2.6.1.27; 2.6.1.57)

Aspartate transaminase (in reverse):
3-(4-hydroxyphenyl)pyruvate + L-glutamate→L-tyrosine + 2-oxoglutarate (EC 2.6.1.1; 2.6.1.27; 2.6.1.5; 2.6.1.57)

Indole-3-glycerol-phosphate synthase:
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H⁺→(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO₂ + H₂O (EC 4.1.1.48)

Indole-3-glycerol-phosphate lyase:
(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate→indole + D-glyceraldehyde 3-phosphate (EC 4.1.2.8; 4.2.1.20)

Shew_2256 (trpA)

indole + L-serine→L-tryptophan + H₂O (EC 4.2.1.122; 4.2.1.20)

Shew_2256 (trpA)

Links:

Pathway details at MetaCyc
Fitness data for 23 genes
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All MetaCyc pathways for Shewanella loihica PV-4

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information