MetaCyc Pathway: sphingolipid biosynthesis (yeast) in Mycobacterium tuberculosis H37Rv

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Serine C-palmitoyltransferase:
stearoyl-CoA + H+ + L-serine→C20 3-dehydrosphinganine + CO2 + coenzyme A (EC 2.3.1.50)
Rv0032
Serine C-palmitoyltransferase:
palmitoyl-CoA + H+ + L-serine→3-dehydrosphinganine + CO2 + coenzyme A (EC 2.3.1.50)
Rv0032
3-dehydrosphinganine reductase (in reverse):
3-dehydrosphinganine + NADPH + H+→sphinganine + NADP+ (EC 1.1.1.102)
No genes
3-dehydrosphinganine reductase (in reverse):
C20 3-dehydrosphinganine + NADPH + H+→C20 sphinganine + NADP+ (EC 1.1.1.102)
No genes
C20 sphinganine + 2 a ferrocytochrome b5 + dioxygen + 2 H+→C20 phytosphingosine + 2 a ferricytochrome b5 + H2O (EC 1.14.18.5)
No genes
sphinganine + 2 a ferrocytochrome b5 + dioxygen + 2 H+→phytosphingosine + 2 a ferricytochrome b5 + H2O (EC 1.14.18.5)
No genes
a phytosphingosine + a very-long-chain fatty acyl-CoA→a very-long-chain phytoceramide + coenzyme A + H+ (EC 2.3.1.297)
No genes
a very-long-chain phytoceramide + 2 a ferrocytochrome b5 + dioxygen + 2 H+→a very-long-chain (2'R)-2'-hydroxy-phytoceramide + 2 a ferricytochrome b5 + H2O (EC 1.14.18.6)
No genes
a very-long-chain (2'R)-2'-hydroxy-phytoceramide + a 1-phosphatidyl-1D-myo-inositol→(4R)-4-hydroxy-N-[(2R)-2-hydroxy-very-long-chain-acyl]-1-O-[(1D-myo-inositol-1-O-yl)hydroxyphosphoryl]sphinganine + a 1,2-diacyl-sn-glycerol (EC 2.7.1.227)
No genes
(4R)-4-hydroxy-N-[(2R)-2-hydroxy-very-long-chain-acyl]-1-O-[(1D-myo-inositol-1-O-yl)hydroxyphosphoryl]sphinganine + GDP-α-D-mannose→(4R)-4-hydroxy-N-[(2R)-2-hydroxy-very-long-chain-acyl]-1-O-{[6-O-(α-D-mannosyl)-1D-myo-inositol-1-O-yl]hydroxyphosphoryl}sphinganine + GDP + H+ (EC 2.4.1.370)
No genes
(4R)-4-hydroxy-N-[(2R)-2-hydroxy-very-long-chain-acyl]-1-O-{[6-O-(α-D-mannosyl)-1D-myo-inositol-1-O-yl]hydroxyphosphoryl}sphinganine + a 1-phosphatidyl-1D-myo-inositol→(4R)-4-hydroxy-N-[(2R)-2-hydroxy-very-long-chain-acyl]-1-O-[hydroxy(6-O-{6-O-[(1D-myo-inositol-1-O-yl)phosphoryl]-α-D-mannosyl}-1D-myo-inositol-1-O-yl)hydroxyphosphoryl]sphinganine + a 1,2-diacyl-sn-glycerol (EC 2.7.1.228)
No genes

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information