MetaCyc Pathway: superpathway of purine nucleotide salvage in Mycobacterium tuberculosis H37Rv

MetaCyc Pathway: superpathway of purine nucleotide salvage in Mycobacterium tuberculosis H37Rv

Adenosine kinase:
adenosine + ATP→AMP + ADP + H⁺ (EC 2.7.1.20)

Purine-nucleoside phosphorylase:
adenosine + phosphate→adenine + α-D-ribose-1-phosphate (EC 2.4.2.1)

Adenylosuccinate synthase:
IMP + L-aspartate + GTP→adenylosuccinate + GDP + 2 H⁺ + phosphate (EC 6.3.4.4)

IMP dehydrogenase:
IMP + NAD⁺ + H₂O→XMP + NADH + H⁺ (EC 1.1.1.205)

Purine-nucleoside phosphorylase:
guanosine + phosphate→guanine + α-D-ribose-1-phosphate (EC 2.4.2.1; 2.4.2.15)

Adenine phosphoribosyltransferase (in reverse):
adenine + 5-phospho-α-D-ribose 1-diphosphate→AMP + diphosphate (EC 2.4.2.7)

Adenylosuccinate lyase:
adenylosuccinate→AMP + fumarate (EC 4.3.2.2)

GMP synthase (glutamine-hydrolyzing):
XMP + ATP + L-glutamine + H₂O→GMP + AMP + L-glutamate + diphosphate + 2 H⁺ (EC 6.3.5.2)

Hypoxanthine phosphoribosyltransferase (in reverse):
guanine + 5-phospho-α-D-ribose 1-diphosphate→GMP + diphosphate (EC 2.4.2.8)

Adenylate kinase:
AMP + ATP→2 ADP (EC 2.7.4.3)

Guanylate kinase:
GMP + ATP→GDP + ADP (EC 2.7.4.8)

Ribonucleoside-diphosphate reductase (in reverse):
ADP + a reduced thioredoxin→dADP + an oxidized thioredoxin + H₂O (EC 1.17.4.1)

Nucleoside-diphosphate kinase:
GDP + ATP→GTP + ADP (EC 2.7.4.6)

Nucleoside-diphosphate kinase:
dADP + ATP→ADP + dATP (EC 2.7.4.6)

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information