MetaCyc Pathway: mycobactin biosynthesis in Mycobacterium tuberculosis H37Rv

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L-lysine 6-monooxygenase (NADPH):
L-lysine + NADPH + dioxygen→N6-hydroxy-L-lysine + NADP+ + H2O (EC 1.14.13.59)
Rv2378c
Long-chain-fatty-acid--[acyl-carrier-protein] ligase:
a long-chain fatty acid + a soluble [acyl-carrier protein] + ATP→a long-chain fatty acyl-[acyl-carrier protein] + AMP + diphosphate (EC 6.2.1.20)
Rv1345
salicylate + ATP + a non-ribosomal peptide synthase→a salicyl-[non-ribosomal peptide synthase] + AMP + diphosphate (EC 6.2.1.61)
Rv2384
L-threonine + ATP + a holo-[L-threonyl-carrier protein]→an L-threonyl-[L-threonyl-carrier protein] + AMP + diphosphate (EC 6.2.1.70)
Rv2383c
[Acyl-carrier-protein] S-malonyltransferase:
malonyl-CoA + an [MbtD non-ribosomal peptide synthase]→a malonyl-[MbtD non-ribosomal peptide synthase] + coenzyme A (EC 2.3.1.39)
Rv0405
Rv0649
Rv2048c
Rv2243
Rv2381c
Rv2382c
Rv2524c
Rv2932
a long-chain fatty acyl-[acyl-carrier protein] + an oxidized electron-transfer flavoprotein + H+→a (2Z)-unsaturated long-chain fatty acyl-[acp] + a reduced electron-transfer flavoprotein
Rv1346
N6-hydroxy-L-lysine + ATP + a holo-[MbtF peptidyl-carrier domain]→N6-hydroxy-L-lysyl-[MbtF peptidyl-carrier domain] + AMP + diphosphate
Rv2379c
a (2Z)-unsaturated long-chain fatty acyl-[acp] + N6-hydroxy-L-lysine→N6-[(2Z)-unsaturated long-chain fatty acyl]-N6-hydroxy-L-lysine + a soluble [acyl-carrier protein]
Rv1347c
N6-[(2Z)-unsaturated long-chain fatty acyl]-N6-hydroxy-L-lysine + ATP + a holo-[MbtE peptidyl-carrier protein]→N6-[(2Z)-unsaturated long-chain fatty acyl]-N6-hydroxy-L-lysyl-[MbtE peptidyl-carrier protein] + AMP + diphosphate
Rv2380c
an L-threonyl-[L-threonyl-carrier protein] + a malonyl-[MbtD non-ribosomal peptide synthase] + N6-[(2Z)-unsaturated long-chain fatty acyl]-N6-hydroxy-L-lysyl-[MbtE peptidyl-carrier protein] + N6-hydroxy-L-lysyl-[MbtF peptidyl-carrier domain] + a salicyl-[non-ribosomal peptide synthase] + 2 NADPH→a pre-mycobactin + an [MbtD non-ribosomal peptide synthase] + a holo-[MbtE peptidyl-carrier protein] + a holo-[MbtF peptidyl-carrier domain] + 2 NADP+ + a non-ribosomal peptide synthase + 2 H2O + a holo-[L-threonyl-carrier protein]
Rv2377c
Rv2379c
Rv2380c
Rv2381c
Rv2382c
Rv2383c
Rv2384
a pre-mycobactin→a mycobactin
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information