MetaCyc Pathway: furaquinocin biosynthesis in Mycobacterium tuberculosis H37Rv

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5 malonyl-CoA + 5 H+→1,3,6,8-naphthalenetetrol + 5 CO2 + 5 coenzyme A + H2O (EC 2.3.1.233)
Rv1660
1,3,6,8-naphthalenetetrol + dioxygen→flaviolin + H+ + H2O
No genes
flaviolin + S-adenosyl-L-methionine→2-O-methylflaviolin + S-adenosyl-L-homocysteine
No genes
2-O-methylflaviolin + S-adenosyl-L-methionine→2-O,3-dimethylflaviolin + S-adenosyl-L-homocysteine + H+
No genes
2-O,3-dimethylflaviolin + geranyl diphosphate→6-linalyl-2-O,3-dimethylflaviolin + diphosphate (EC 2.5.1.124)
No genes
6-linalyl-2-O,3-dimethylflaviolin→furaquinocin C
No genes
furaquinocin C + dioxygen + 2 H+ + 2 a reduced ferredoxin [iron-sulfur] cluster→furaquinocin D + 2 an oxidized ferredoxin [iron-sulfur] cluster + H2O
No genes
furaquinocin D + dioxygen + 2 H+ + 2 a reduced ferredoxin [iron-sulfur] cluster→furaquinocin A + 2 an oxidized ferredoxin [iron-sulfur] cluster + H2O
No genes

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information