MetaCyc Pathway: adipate biosynthesis in Mycobacterium tuberculosis H37Rv

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3-oxoadipyl-CoA thiolase:
acetyl-CoA + succinyl-CoA→3-oxoadipoyl-CoA + coenzyme A (EC 2.3.1.174)
No genes
3-hydroxyacyl-CoA dehydrogenase (in reverse):
3-oxoadipoyl-CoA + NADH + H+→(3S)-hydroxyadipyl-CoA + NAD+ (EC 1.1.1.35)
Rv0468
Rv0860
Rv1144
Enoyl-CoA hydratase:
(3S)-hydroxyadipyl-CoA→(2E)-5-carboxy-2-pentenoyl-CoA + H2O (EC 4.2.1.17)
Rv0130
Rv0222
Rv0456c
Rv0632c
Rv0673
Rv0675
Rv0860
Rv0905
Rv0971c
Rv1070c
Rv1071c
Rv1136
Rv1141c
Rv1142c
Rv1472
Rv1935c
Rv2486
Rv2679
Rv2831
Rv3039c
Rv3373
Rv3374
Rv3516
Rv3550
Rv3774
(2E)-5-carboxy-2-pentenoyl-CoA + FADH2→adipoyl-CoA + FAD + H+
Rv3274c
Succinate--CoA ligase (ADP-forming) (in reverse):
adipoyl-CoA + ADP + phosphate→adipate + ATP + coenzyme A (EC 6.2.1.5)
Rv0951
Rv0952

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information