MetaCyc Pathway: mycofactocin biosynthesis in Mycobacterium tuberculosis H37Rv

Add experiment(s):


a C-terminal [mycofactocin precursor peptide]-glycyl-L-valyl-L-tyrosine + S-adenosyl-L-methionine→a C-terminal [mycofactocin precursor peptide]-glycyl-L-valyl-decarboxylated L-tyrosine + CO2 + 5'-deoxyadenosine + L-methionine (EC 1.3.98.7)
Rv0692
Rv0693
a C-terminal [mycofactocin precursor peptide]-glycyl-L-valyl-decarboxylated L-tyrosine + a reduced two electron carrier + S-adenosyl-L-methionine→a C-terminal [mycofactocin precursor peptide]-glycyl-3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethylpyrrolidin-2-one + an oxidized electron carrier + 5'-deoxyadenosine + L-methionine + H+ (EC 4.1.99.26)
Rv0692
Rv0693
a C-terminal [mycofactocin precursor peptide]-glycyl-3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethylpyrrolidin-2-one + H2O→3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-2-pyrrolidin-2-one + a C-terminal [mycofactocin precursor peptide]-glycine (EC 3.4.14.14)
Rv0695
3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-2-pyrrolidin-2-one + dioxygen→5-[(4-hydroxyphenyl)methyl]-3-imino-4,4-dimethylpyrrolidin-2-one + hydrogen peroxide + H+ (EC 1.4.3.26)
No genes
5-[(4-hydroxyphenyl)methyl]-3-imino-4,4-dimethylpyrrolidin-2-one + H+ + H2O→PMFT + ammonium (spontaneous) (EC 1.4.3.26)
No genes
PMFT + UDP-α-D-glucose→MFT-1 + H+ + UDP (EC 2.4.1.M64)
Rv0696
MFT-1 + UDP-α-D-glucose→MFT-2 + H+ + UDP (EC 2.4.1.M64)
Rv0696
MFT-2 + S-adenosyl-L-methionine→MMFT-2 + S-adenosyl-L-homocysteine + H+
No genes
MMFT-2 + UDP-α-D-glucose→MMFT-3 + H+ + UDP (EC 2.4.1.M64)
Rv0696
MMFT-3 + UDP-α-D-glucose→MMFT-4 + H+ + UDP (EC 2.4.1.M64)
Rv0696
MMFT-4 + UDP-α-D-glucose→MMFT-5 + H+ + UDP (EC 2.4.1.M64)
Rv0696
MMFT-5 + UDP-α-D-glucose→MMFT-6 + H+ + UDP (EC 2.4.1.M64)
Rv0696
MMFT-6 + UDP-α-D-glucose→MMFT-7 + H+ + UDP (EC 2.4.1.M64)
Rv0696
MMFT-7 + UDP-α-D-glucose→MMFT-8 + H+ + UDP (EC 2.4.1.M64)
Rv0696
MMFT-8 + UDP-α-D-glucose→MMFT-9 + H+ + UDP (EC 2.4.1.M64)
Rv0696

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information