MetaCyc Pathway: protein Pupylation and dePupylation in Mycobacterium tuberculosis H37Rv

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a [prokaryotic ubiquitin-like protein] C-terminal L-glutamine + H2O→a [prokaryotic ubiquitin-like protein] C-terminal L-glutamate + ammonium + H+ (EC 3.5.1.119)
Rv2112c
a [prokaryotic ubiquitin-like protein] C-terminal L-glutamate + ATP + a [protein]-L-lysine→N6-([prokaryotic ubiquitin-like protein]-γ-L-glutamyl)-[protein]-L-lysine + ADP + H+ + phosphate (EC 6.3.1.19)
Rv2097c
N6-([prokaryotic ubiquitin-like protein]-γ-L-glutamyl)-[protein]-L-lysine + H2O→a [prokaryotic ubiquitin-like protein] C-terminal L-glutamate + a [protein]-L-lysine (EC 3.4.99.M1)
Rv2112c

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information