MetaCyc Pathway: indolmycin biosynthesis in Mycobacterium tuberculosis H37Rv

Add experiment(s):


L-tryptophan + pyruvate→(indol-3-yl)pyruvate + L-alanine (EC 2.6.1.99)
Rv1600
L-arginine + NAD+→4,5-dehydro-L-arginine + NADH + H+
No genes
Indolepyruvate C-methyltransferase:
(indol-3-yl)pyruvate + S-adenosyl-L-methionine→(R)-3-(indol-3-yl)-2-oxobutanoate + S-adenosyl-L-homocysteine + H+ (EC 2.1.1.47)
No genes
(R)-3-(indol-3-yl)-2-oxobutanoate + NADH + H+→indolmycenate + NAD+ (EC 1.1.1.397)
No genes
indolmycenate + 4,5-dehydro-L-arginine + ATP→(2R,4E)-2-amino-5-({[(2S,3R)-2-hydroxy-3-(1H-indol-3-yl)butanamido]methanimidoyl}amino)pent-4-enoate + AMP + diphosphate + H+
No genes
(2R,4E)-2-amino-5-({[(2S,3R)-2-hydroxy-3-(1H-indol-3-yl)butanamido]methanimidoyl}amino)pent-4-enoate→N-demethylindolmycin + (2S)-2-amino-5-iminopentanoate
No genes
(2R,4E)-2-amino-5-({[(2S,3R)-2-hydroxy-3-(1H-indol-3-yl)butanamido]methanimidoyl}amino)pent-4-enoate + H+→indolmycin B + ammonium (spontaneous)
No genes
(2S)-2-amino-5-iminopentanoate + H+ + H2O→L-glutamate 5-semialdehyde + ammonium
No genes
N-demethylindolmycin + S-adenosyl-L-methionine→indolmycin + S-adenosyl-L-homocysteine + H+ (EC 2.1.1.328)
No genes
L-glutamate 5-semialdehyde→(S)-1-pyrroline-5-carboxylate + H+ + H2O (spontaneous)
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information