MetaCyc Pathway: mycobacterial sulfolipid biosynthesis in Mycobacterium tuberculosis H37Rv

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α,α-trehalose + 3'-phosphoadenylyl-sulfate→2-O-sulfo-α,α-trehalose + adenosine 3',5'-bisphosphate + H+ (EC 2.8.2.37)
Rv0295c
Oleoyl-[acyl-carrier-protein] hydrolase:
a palmitoyl-[acp] + H2O→palmitate + a soluble [acyl-carrier protein] + H+ (EC 3.1.2.14)
No genes
a palmitoyl-[acp] + coenzyme A→palmitoyl-CoA + a soluble [acyl-carrier protein]
No genes
2-O-sulfo-α,α-trehalose + palmitoyl-CoA→2'-palmitoyl-2-O-sulfo-α,α-trehalose + coenzyme A (EC 2.3.1.288)
Rv3820c
palmitate + ATP + H+→(palmitoyl)adenylate + diphosphate (EC 6.2.1.57)
No genes
(palmitoyl)adenylate + a holo-[(hydroxy)phthioceranic acid synthase]→a palmitoyl-[(hydroxy)phthioceranic acid synthase] + AMP + H+ (EC 6.2.1.57)
No genes
a palmitoyl-[(hydroxy)phthioceranic acid synthase] + 7 (S)-methylmalonyl-CoA + 13 NADPH + 20 H+→a C37-hydroxyphthioceranyl-[(hydroxy)phthioceranic acid synthase] + 7 CO2 + 7 coenzyme A + 13 NADP+ + 6 H2O (EC 2.3.1.287)
Rv3825c
a C37-hydroxyphthioceranyl-[(hydroxy)phthioceranic acid synthase] + 2'-palmitoyl-2-O-sulfo-α,α-trehalose→SL1278 + a holo-[(hydroxy)phthioceranic acid synthase] (EC 2.3.1.283)
Rv3824c
3 SL1278→2 2'-palmitoyl-2-O-sulfo-α,α-trehalose + sulfolipid-2 (EC 2.3.1.284)
Rv3822

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information