MetaCyc Pathway: dimycocerosyl phthiocerol biosynthesis in Mycobacterium tuberculosis H37Rv

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a long-chain fatty acid + ATP + H+→a long-chain fatty-acyl adenylate ester + diphosphate (EC 6.2.1.49; 6.2.1.59)
No genes
a long-chain fatty-acyl adenylate ester + a holo-[mycocerosic acid synthase]→a long-chain fatty acyl-[mycocerosic acid synthase] + AMP + H+ (EC 6.2.1.49)
No genes
Mycocerosate synthase:
a long-chain fatty acyl-[mycocerosic acid synthase] + n (S)-methylmalonyl-CoA + 2n NADPH + 3n H+→a mycocerosyl-[mycocerosic acid synthase] + n CO2 + n coenzyme A + 2n NADP+ + n H2O (EC 2.3.1.111)
Rv2940c
2 a mycocerosyl-[mycocerosic acid synthase] + a phthiocerol→a dimycocerosyl phthiocerol + 2 a holo-[mycocerosic acid synthase] (EC 2.3.1.282)
Rv2939

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information