MetaCyc Pathway: phthiocerol biosynthesis in Mycobacterium tuberculosis H37Rv

Add experiment(s):


behenate + ATP + H+→(behenoyl)adenylate + diphosphate (EC 6.2.1.59)
No genes
(behenoyl)adenylate + a holo-[(phenol)carboxyphthiodiolenone synthase]→a behenoyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + H+ (EC 6.2.1.59)
No genes
a behenoyl-[(phenol)carboxyphthiodiolenone synthase] + 2 (S)-methylmalonyl-CoA + 3 malonyl-CoA + 5 NADPH + 10 H+→a C34-carboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase] + 5 CO2 + 5 coenzyme A + 5 NADP+ + 2 H2O (EC 2.3.1.292)
Rv2931
Rv2933
Rv2934
Rv2935
a C34-carboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase] + H2O→C34-carboxyphthiodiolenone + H+ + a holo-[(phenol)carboxyphthiodiolenone synthase] (EC 3.1.2.M1)
Rv2928
C34-carboxyphthiodiolenone + H+→C33-phthiodiolenone A + CO2 (EC 4.1.1.M4)
No genes
C33-phthiodiolenone A + NADPH + H+→C33-phthiodiolone A + NADP+ (EC 1.1.1.M10)
Rv2449c
Rv2953
C33-phthiodiolone A + NADPH + H+→C33-phthiotriol A + NADP+ (EC 1.1.1.M11)
Rv2951c
C33-phthiotriol A + S-adenosyl-L-methionine→C34-phthiocerol A + S-adenosyl-L-homocysteine + H+ (EC 2.1.1.M12)
Rv2952

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information