MetaCyc Pathway: polyacyltrehalose biosynthesis in Mycobacterium tuberculosis H37Rv

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a holo mycolipanoic acid synthase + 3 (S)-methylmalonyl-CoA + a long-chain fatty acyl-CoA + 6 NADPH + 6 H+→a mycolipanoyl-[mycolipanoic acid synthase] + 3 CO2 + 4 coenzyme A + 6 NADP+ + 3 H2O (EC 2.3.1.252)
No genes
α,α-trehalose + a long-chain fatty acyl-CoA→a 2-(long-chain-fatty acyl)-trehalose + coenzyme A (EC 2.3.1.279)
Rv1182
a mycolipanoyl-[mycolipanoic acid synthase] + H2O→a holo mycolipanoic acid synthase + a mycolipanoate + H+ (EC 3.1.2.M3)
No genes
a mycolipanoate + ATP + coenzyme A→a mycolipanoyl-CoA + AMP + diphosphate (EC 6.2.1.M2)
No genes
a mycolipanoyl-CoA + a reduced two electron carrier + dioxygen→a mycolipenoyl-CoA + an oxidized electron carrier + 2 H2O (EC 1.14.19.M9)
No genes
a 2-(long-chain-fatty acyl)-trehalose + a mycolipenoyl-CoA→a 2-(long-chain fatty acyl)-3-mycolipenoyl-trehalose + coenzyme A (EC 2.3.1.278)
Rv1182
4 a 2-(long-chain fatty acyl)-3-mycolipenoyl-trehalose→3 a 2-(long-chain-fatty acyl)-trehalose + a 2-(long-chain fatty acyl)-2',3,4',6-tetramycolipenoyl-trehalose (EC 2.3.1.M11)
Rv1184c

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information