MetaCyc Pathway: sphingolipid biosynthesis (mammals) in Mycobacterium tuberculosis H37Rv

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Serine C-palmitoyltransferase:
palmitoyl-CoA + H+ + L-serine→3-dehydrosphinganine + CO2 + coenzyme A (EC 2.3.1.50)
Rv0032
3-dehydrosphinganine reductase (in reverse):
3-dehydrosphinganine + NADPH + H+→sphinganine + NADP+ (EC 1.1.1.102)
No genes
Sphingosine N-acyltransferase:
sphinganine + an acyl-CoA→a dihydroceramide + coenzyme A + H+ (EC 2.3.1.24)
No genes
a dihydroceramide + 2 a ferrocytochrome b5 + dioxygen + 2 H+→an N-acylsphingosine + 2 a ferricytochrome b5 + 2 H2O (EC 1.14.19.17)
No genes
Sphingomyelin synthase:
an N-acylsphingosine + a phosphatidylcholine→an N-acyl-sphingosylphosphorylcholine + a 1,2-diacyl-sn-glycerol (EC 2.7.8.27)
No genes
an N-acyl-sphingosylphosphorylcholine + H2O→sphingosylphosphorylcholine + a fatty acid (EC 3.5.1.109)
No genes
Sphingomyelin phosphodiesterase:
an N-acyl-sphingosylphosphorylcholine + H2O→an N-acylsphingosine + phosphocholine + H+ (EC 3.1.4.12)
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information