MetaCyc Pathway: benzoate biosynthesis I (CoA-dependent, β-oxidative) in Mycobacterium tuberculosis H37Rv

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Phenylalanine ammonia-lyase:
L-phenylalanine→trans-cinnamate + ammonium (EC 4.3.1.24; 4.3.1.25; 5.4.3.10)
No genes
trans-cinnamate + ATP + coenzyme A→(E)-cinnamoyl-CoA + AMP + diphosphate
No genes
Enoyl-CoA hydratase (in reverse):
(E)-cinnamoyl-CoA + H2O→(S)-3-hydroxy-3-phenylpropanoyl-CoA (EC 4.2.1.17)
Rv0130
Rv0222
Rv0456c
Rv0632c
Rv0673
Rv0675
Rv0860
Rv0905
Rv0971c
Rv1070c
Rv1071c
Rv1136
Rv1141c
Rv1142c
Rv1472
Rv1935c
Rv2486
Rv2679
Rv2831
Rv3039c
Rv3373
Rv3374
Rv3516
Rv3550
Rv3774
3-hydroxyacyl-CoA dehydrogenase:
(S)-3-hydroxy-3-phenylpropanoyl-CoA + NAD+→3-oxo-3-phenylpropanoyl-CoA + NADH + H+ (EC 1.1.1.35)
Rv0468
Rv0860
Rv1144
Acetyl-CoA C-acyltransferase (in reverse):
3-oxo-3-phenylpropanoyl-CoA + coenzyme A→benzoyl-CoA + acetyl-CoA (EC 2.3.1.16)
Rv0243
Rv0859
Rv0914c
Rv1074c
Rv1135A
Rv1323
Rv2790c
Rv3523
Rv3546
Rv3556c
benzoyl-CoA + H2O→benzoate + coenzyme A + H+
No genes
Benzoate--CoA ligase:
benzoate + ATP + coenzyme A→benzoyl-CoA + AMP + diphosphate (EC 6.2.1.25)
No genes
benzoyl-CoA + benzyl alcohol→benzyl benzoate + coenzyme A (EC 2.3.1.196)
No genes
benzyl benzoate + H2O→benzoate + benzyl alcohol + H+
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information