MetaCyc Pathway: glutaryl-CoA degradation in Mycobacterium tuberculosis H37Rv

MetaCyc Pathway: glutaryl-CoA degradation in Mycobacterium tuberculosis H37Rv

glutaryl-CoA + an oxidized electron-transfer flavoprotein + H⁺→(E)-glutaconyl-CoA + a reduced electron-transfer flavoprotein (EC 1.3.8.6)

No genes

(E)-glutaconyl-CoA + H⁺→crotonyl-CoA + CO₂ (EC 1.3.8.6)

No genes

crotonyl-CoA + H₂O→(S)-3-hydroxybutanoyl-CoA (EC 4.2.1.150)

3-hydroxyacyl-CoA dehydrogenase:
(S)-3-hydroxybutanoyl-CoA + NAD⁺→acetoacetyl-CoA + NADH + H⁺ (EC 1.1.1.35)

Acetyl-CoA C-acyltransferase (in reverse):
acetoacetyl-CoA + coenzyme A→2 acetyl-CoA (EC 2.3.1.16; 2.3.1.9)

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information