MetaCyc Pathway: lactate fermentation to acetate, CO<sub>2</sub> and hydrogen (<i>Desulfovibrionales</i>) in Desulfovibrio vulgaris Miyazaki F

MetaCyc Pathway: lactate fermentation to acetate, CO₂ and hydrogen (Desulfovibrionales) in Desulfovibrio vulgaris Miyazaki F

D-lactate dehydrogenase (cytochrome c-553):
(R)-lactate + 2 an oxidized cytochrome c-553→pyruvate + 2 H⁺ + 2 a reduced cytochrome c-553 (EC 1.1.2.5)

L-lactate dehydrogenase (cytochrome):
(S)-lactate + 2 an oxidized c-type cytochrome→pyruvate + 2 a reduced c-type cytochrome + 2 H⁺ (EC 1.1.2.3)

Pyruvate synthase:
pyruvate + coenzyme A + 2 an oxidized ferredoxin [iron-sulfur] cluster→acetyl-CoA + CO₂ + 2 a reduced ferredoxin [iron-sulfur] cluster + H⁺ (EC 1.2.7.1)

Phosphate acetyltransferase:
acetyl-CoA + phosphate→acetyl phosphate + coenzyme A (EC 2.3.1.8)

CO₂ + 2 a reduced type I cytochrome c₃ + H⁺→formate + 2 an oxidized type I cytochrome c₃ (EC 1.17.2.3)

a reduced ferredoxin [iron-sulfur] cluster + an oxidized type I cytochrome c₃→a reduced type I cytochrome c₃ + an oxidized ferredoxin [iron-sulfur] cluster

No genes

Acetate kinase (in reverse):
acetyl phosphate + ADP→acetate + ATP (EC 2.7.2.1; 2.7.2.15)

DvMF_2756 (purT)

Cytochrome-c3 hydrogenase (in reverse):
2 a reduced type I cytochrome c₃ + 2 H⁺→H₂ + 2 an oxidized type I cytochrome c₃ (EC 1.12.2.1)

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information