MetaCyc Pathway: incomplete reductive TCA cycle in Methanococcus maripaludis JJ

MetaCyc Pathway: incomplete reductive TCA cycle in Methanococcus maripaludis JJ

Pyruvate synthase (in reverse):
acetyl-CoA + CO₂ + H⁺ + 2 a reduced ferredoxin [iron-sulfur] cluster→pyruvate + coenzyme A + 2 an oxidized ferredoxin [iron-sulfur] cluster (EC 1.2.7.1)

Pyruvate carboxylase:
pyruvate + ATP + hydrogen carbonate→oxaloacetate + ADP + H⁺ + phosphate (EC 6.4.1.1)

Malate dehydrogenase (in reverse):
oxaloacetate + NADH + H⁺→(S)-malate + NAD⁺ (EC 1.1.1.37; 1.1.1.38)

Fumarate hydratase:
(S)-malate→fumarate + H₂O (EC 4.2.1.2)

Succinate dehydrogenase (ubiquinone):
fumarate_[in] + a menaquinol→succinate_[in] + a menaquinone (EC 1.3.5.1)

No genes

Succinate--CoA ligase (ADP-forming):
succinate + ATP + coenzyme A→succinyl-CoA + ADP + phosphate (EC 6.2.1.5)

2-oxoglutarate synthase (in reverse):
succinyl-CoA + CO₂ + H⁺ + 2 a reduced ferredoxin [iron-sulfur] cluster→2-oxoglutarate + coenzyme A + 2 an oxidized ferredoxin [iron-sulfur] cluster (EC 1.2.7.3)

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Pathway details at MetaCyc
Fitness data for 19 genes
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All MetaCyc pathways for Methanococcus maripaludis JJ

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information