MetaCyc Pathway: methanogenesis from H₂ and CO₂ in Methanococcus maripaludis JJ

CO2 + a methanofuran + H+ + 2 a reduced ferredoxin [iron-sulfur] cluster→a formylmethanofuran + 2 an oxidized ferredoxin [iron-sulfur] cluster + H2O (EC 1.2.7.12)

MMJJ_RS00850

MMJJ_RS05650

MMJJ_RS07925

MMJJ_RS07930

MMJJ_RS07935

Formylmethanofuran--tetrahydromethanopterin N-formyltransferase: a formylmethanofuran + H+ + tetrahydromethanopterin→5-formyl-tetrahydromethanopterin + a methanofuran (EC 2.3.1.101)

MMJJ_RS06095

Methenyltetrahydromethanopterin cyclohydrolase (in reverse): 5-formyl-tetrahydromethanopterin + H+→5,10-methenyltetrahydromethanopterin + H2O (EC 3.5.4.27)

MMJJ_RS08220

5,10-methenyltetrahydromethanopterin hydrogenase: 5,10-methenyltetrahydromethanopterin + H2→5,10-methylene-tetrahydromethanopterin + H+ (EC 1.12.98.2)

MMJJ_RS04750

5,10-methylene-tetrahydromethanopterin + a reduced factor 420→5-methyltetrahydromethanopterin + an oxidized factor 420 (EC 1.5.98.2)

MMJJ_RS05145

Tetrahydromethanopterin S-methyltransferase: 5-methyltetrahydromethanopterin[in] + coenzyme M[in] + 2 Na+[in]→methyl-CoM[in] + 2 Na+[out] + tetrahydromethanopterin[in] (EC 2.1.1.86)

MMJJ_RS06300

MMJJ_RS06305

MMJJ_RS06310

MMJJ_RS06315

MMJJ_RS06320

MMJJ_RS06325

MMJJ_RS06330

MMJJ_RS06335

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information