MetaCyc Pathway: 2-methyl-branched fatty acid β-oxidation in Marinobacter adhaerens HP15

Add experiment(s):


Butyrate--CoA ligase:
a short-chain 2-methyl-branched fatty acid + ATP + coenzyme A→a short-chain 2-methyl fatty acyl-CoA + AMP + diphosphate (EC 6.2.1.2)
No genes
a long-chain 2-methyl fatty acyl-CoA + an oxidized electron-transfer flavoprotein + H+→a long-chain (2E)-2-methyl-2-enoyl-CoA + a reduced electron-transfer flavoprotein (EC 1.3.8.8)
HP15_56
HP15_618
Butyrate--CoA ligase:
a medium-chain 2-methyl-branched fatty acid + ATP + coenzyme A→a medium-chain 2-methyl fatty acyl-CoA + AMP + diphosphate (EC 6.2.1.2)
No genes
a short-chain 2-methyl fatty acyl-CoA + an oxidized electron-transfer flavoprotein + H+→a short-chain (2E)-2-methyl-2-enoyl-CoA + a reduced electron-transfer flavoprotein (EC 1.3.8.5)
No genes
a medium-chain 2-methyl fatty acyl-CoA + an oxidized electron-transfer flavoprotein + H+→a medium-chain (2E)-2-methyl-2-enoyl-CoA + a reduced electron-transfer flavoprotein (EC 1.3.8.7)
HP15_2478
HP15_2479
HP15_267
HP15_3339
HP15_3696
HP15_56
HP15_618
Enoyl-CoA hydratase (in reverse):
a long-chain (2E)-2-methyl-2-enoyl-CoA + H2O→a long-chain (3S)-3-hydroxy-2-methylacyl-CoA (EC 4.2.1.17)
HP15_1141
HP15_12
HP15_1232
HP15_1512
HP15_1737
HP15_1740
HP15_2575
HP15_2692
HP15_2717
HP15_3410
HP15_3941
HP15_4082
HP15_4094
HP15_55
HP15_864
HP15_908
HP15_909
Enoyl-CoA hydratase (in reverse):
a short-chain (2E)-2-methyl-2-enoyl-CoA + H2O→a short-chain (3S)-3-hydroxy-2-methylacyl-CoA (EC 4.2.1.17)
HP15_1141
HP15_12
HP15_1232
HP15_1512
HP15_1737
HP15_1740
HP15_2575
HP15_2692
HP15_2717
HP15_3410
HP15_3941
HP15_4082
HP15_4094
HP15_55
HP15_864
HP15_908
HP15_909
Enoyl-CoA hydratase (in reverse):
a medium-chain (2E)-2-methyl-2-enoyl-CoA + H2O→a medium-chain (3S)-3-hydroxy-2-methylacyl-CoA (EC 4.2.1.17)
HP15_1141
HP15_12
HP15_1232
HP15_1512
HP15_1737
HP15_1740
HP15_2575
HP15_2692
HP15_2717
HP15_3410
HP15_3941
HP15_4082
HP15_4094
HP15_55
HP15_864
HP15_908
HP15_909
3-hydroxyacyl-CoA dehydrogenase:
a long-chain (3S)-3-hydroxy-2-methylacyl-CoA + NAD+→a long-chain 2-methyl-3-oxoacyl-CoA + NADH + H+ (EC 1.1.1.35)
HP15_1232
HP15_1512
HP15_3941
HP15_48
3-hydroxy-2-methylbutyryl-CoA dehydrogenase:
a short-chain (3S)-3-hydroxy-2-methylacyl-CoA + NAD+→a short-chain 2-methyl-3-oxoacyl-CoA + NADH + H+ (EC 1.1.1.178)
No genes
3-hydroxyacyl-CoA dehydrogenase:
a medium-chain (3S)-3-hydroxy-2-methylacyl-CoA + NAD+→a medium-chain 2-methyl-3-oxoacyl-CoA + NADH + H+ (EC 1.1.1.35)
HP15_1232
HP15_1512
HP15_3941
HP15_48
Acetyl-CoA C-acyltransferase (in reverse):
a long-chain 2-methyl-3-oxoacyl-CoA + coenzyme A→a long-chain 2-methyl fatty acyl-CoA + propanoyl-CoA (EC 2.3.1.16)
HP15_1009
HP15_1233
HP15_1513
HP15_2344
HP15_2423
HP15_2695
HP15_2996
HP15_35
HP15_3943
HP15_49
HP15_5
Acetyl-CoA C-acyltransferase (in reverse):
a short-chain 2-methyl-3-oxoacyl-CoA + coenzyme A→a short-chain 2-methyl fatty acyl-CoA + propanoyl-CoA (EC 2.3.1.16)
HP15_1009
HP15_1233
HP15_1513
HP15_2344
HP15_2423
HP15_2695
HP15_2996
HP15_35
HP15_3943
HP15_49
HP15_5
Acetyl-CoA C-acyltransferase (in reverse):
a medium-chain 2-methyl-3-oxoacyl-CoA + coenzyme A→a medium-chain 2-methyl fatty acyl-CoA + propanoyl-CoA (EC 2.3.1.16)
HP15_1009
HP15_1233
HP15_1513
HP15_2344
HP15_2423
HP15_2695
HP15_2996
HP15_35
HP15_3943
HP15_49
HP15_5

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information