MetaCyc Pathway: cannabinoid biosynthesis in Marinobacter adhaerens HP15

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Butyrate--CoA ligase:
hexanoate + ATP + coenzyme A→hexanoyl-CoA + AMP + diphosphate (EC 6.2.1.2)
HP15_1039
hexanoyl-CoA + 2 malonyl-CoA + 2 H+→3,5-dioxodecanoyl-CoA + 2 CO2 + 2 coenzyme A (EC 2.3.1.206)
No genes
3,5-dioxodecanoyl-CoA + malonyl-CoA + H+→3,5,7-trioxododecanoyl-CoA + CO2 + coenzyme A (EC 2.3.1.206)
No genes
3,5,7-trioxododecanoyl-CoA→olivetolate + coenzyme A + H+ (EC 4.4.1.26)
No genes
olivetolate + geranyl diphosphate→cannabigerolate + diphosphate (EC 2.5.1.102)
No genes
cannabigerolate + dioxygen→Δ9-tetrahydrocannabinolate + hydrogen peroxide (EC 1.21.3.7)
No genes
cannabigerolate + dioxygen→cannabidiolate + hydrogen peroxide (EC 1.21.3.8)
No genes
cannabigerolate + an oxidized electron carrier→cannabichromenate + a reduced two electron carrier
No genes
Δ9-tetrahydrocannabinolate + dioxygen→cannabinolate + 2 H2O (spontaneous)
No genes
Δ9-tetrahydrocannabinolate + H+→Δ9-tetrahydrocannabinol + CO2 (spontaneous)
No genes
cannabidiolate + H+→cannabidiol + CO2 (spontaneous)
No genes
cannabichromenate + H+→cannabichromene + CO2 (spontaneous)
No genes
cannabinolate + H+→cannabinol + CO2 (spontaneous)
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information