MetaCyc Pathway: bile acid 7α-dehydroxylation in Shewanella oneidensis MR-1

Add experiment(s):


Cholate--CoA ligase:
cholate + ATP + coenzyme A→choloyl-CoA + AMP + diphosphate (EC 6.2.1.7)
No genes
Cholate--CoA ligase:
chenodeoxycholate + ATP + coenzyme A→chenodeoxycholoyl-CoA + AMP + diphosphate (EC 6.2.1.7)
No genes
choloyl-CoA + NAD+→3-dehydrocholoyl-CoA + NADH + H+ (EC 1.1.1.395)
SO1683
chenodeoxycholoyl-CoA + NAD+→3-dehydrochenodeoxycholoyl-CoA + NADH + H+ (EC 1.1.1.395)
SO1683
3-dehydrocholoyl-CoA + NAD+→7α,12α-dihydroxy-3-oxochol-4-en-24-oyl-CoA + NADH + H+ (EC 1.3.1.115)
No genes
3-dehydrochenodeoxycholoyl-CoA + NAD+→7α-hydroxy-3-oxochol-4-en-24-oyl-CoA + NADH + H+ (EC 1.3.1.115)
No genes
7α,12α-dihydroxy-3-oxochol-4-en-24-oyl-CoA + cholate→choloyl-CoA + 7α,12α-dihydroxy-3-oxochol-4-enoate (EC 2.8.3.25)
No genes
cholate + 7α-hydroxy-3-oxochol-4-en-24-oyl-CoA→choloyl-CoA + 7α-hydroxy-3-oxochol-4-enoate (EC 2.8.3.25)
No genes
Bile-acid 7-alpha-dehydratase:
7α,12α-dihydroxy-3-oxochol-4-enoate→12-α-hydroxy-3 oxochola-4,6-dienoate + H2O (EC 4.2.1.106)
No genes
Bile-acid 7-alpha-dehydratase:
7α-hydroxy-3-oxochol-4-enoate→3-oxochol-4,6-dienoate + H2O (EC 4.2.1.106)
No genes
12-α-hydroxy-3 oxochola-4,6-dienoate + NADH + H+→12-α-hydroxy-3 oxochol-4-enoate + NAD+ (EC 1.3.1.114)
No genes
3-oxochol-4,6-dienoate + NADH + H+→3-oxochol-4-en-24-oate + NAD+ (EC 1.3.1.114)
No genes
12-α-hydroxy-3 oxochol-4-enoate + NADH + H+→3-dehydrodeoxycholate + NAD+ (EC 1.3.1.114)
No genes
3-oxochol-4-en-24-oate + NADH + H+→3-dehydrolithocholate + NAD+ (EC 1.3.1.114)
No genes
3-alpha-hydroxycholanate dehydrogenase (in reverse):
3-dehydrolithocholate + NADH + H+→lithocholate + NAD+ (EC 1.1.1.52)
No genes
3-alpha-hydroxycholanate dehydrogenase (in reverse):
3-dehydrodeoxycholate + NADH + H+→deoxycholate + NAD+ (EC 1.1.1.52)
No genes

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information