MetaCyc Pathway: superpathway of heme b biosynthesis from glutamate in Shewanella oneidensis MR-1

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Glutamate--tRNA ligase:
L-glutamate + ATP + a tRNAglu→an L-glutamyl-[tRNAGlu] + AMP + diphosphate (EC 6.1.1.17)
SO3128.2
Glutamyl-tRNA reductase (in reverse):
an L-glutamyl-[tRNAGlu] + NADPH + H+→(S)-4-amino-5-oxopentanoate + a tRNAglu + NADP+ (EC 1.2.1.70)
SO3834 (hemA)
Glutamate-1-semialdehyde 2,1-aminomutase:
(S)-4-amino-5-oxopentanoate→5-aminolevulinate (EC 5.4.3.8)
SO1300 (hemL)
Porphobilinogen synthase:
2 5-aminolevulinate→porphobilinogen + H+ + 2 H2O (EC 4.2.1.24)
SO2587 (hemB-1)
SO4208 (hemB-2)
Hydroxymethylbilane synthase:
4 porphobilinogen + H2O→preuroporphyrinogen + 4 ammonium (EC 2.5.1.61)
SO4313 (hemC)
Uroporphyrinogen-III synthase:
preuroporphyrinogen→uroporphyrinogen-III + H2O (EC 4.2.1.75)
SO4314 (hemD)
Uroporphyrinogen decarboxylase:
uroporphyrinogen-III + 4 H+→coproporphyrinogen III + 4 CO2 (EC 4.1.1.37)
SO0435 (hemE)
Coproporphyrinogen oxidase:
coproporphyrinogen III + dioxygen + 2 H+→protoporphyrinogen IX + 2 CO2 + 2 H2O (EC 1.3.3.3)
SO0038 (hemF)
Protoporphyrinogen oxidase:
protoporphyrinogen IX + 3 dioxygen→protoporphyrin IX + 3 hydrogen peroxide (EC 1.3.3.4)
SO0025
SO0027
SO3720
protoporphyrin IX + Fe2+→protoheme + 2 H+ (EC 4.98.1.1)
SO0740
SO2019 (hemH-1)
SO3348 (hemH-2)

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information