MetaCyc Pathway: lipid IVA biosynthesis (Vibrio cholerae serogroup O1 El Tor) in Lysobacter sp. OAE881

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Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase:
UDP-N-acetyl-α-D-glucosamine + a (3R)-3-hydroxydodecanoyl-[acp]→UDP-3-O-[(3R)-3-hydroxydodecanoyl]-N-acetyl-α-D-glucosamine + a soluble [acyl-carrier protein] (EC 2.3.1.129)
ABIE51_RS06885
UDP-3-O-[(3R)-3-hydroxydodecanoyl]-N-acetyl-α-D-glucosamine + H2O→UDP-3-O-[(3R)-3-hydroxydodecanoyl]-α-D-glucosamine + acetate (EC 3.5.1.108)
ABIE51_RS04775
UDP-3-O-[(3R)-3-hydroxydodecanoyl]-α-D-glucosamine + a (3R)-3-hydroxytetradecanoyl-[acp]→UDP-2-N-[(3R)-3-hydroxytetradecanoyl]-3-O-[(3R)-3-hydroxydodecanoyl]-α-D-glucosamine + a soluble [acyl-carrier protein] + H+ (EC 2.3.1.191)
ABIE51_RS06895
UDP-2-N-[(3R)-3-hydroxytetradecanoyl]-3-O-[(3R)-3-hydroxydodecanoyl]-α-D-glucosamine + H2O→lipid X (Vibrio cholerae serogroup O1 El Tor) + 2 H+ + UMP (EC 3.6.1.54)
ABIE51_RS06195
ABIE51_RS16470
Lipid-A-disaccharide synthase:
lipid X (Vibrio cholerae serogroup O1 El Tor) + UDP-2-N-[(3R)-3-hydroxytetradecanoyl]-3-O-[(3R)-3-hydroxydodecanoyl]-α-D-glucosamine→lipid A disaccharide (Vibrio cholerae serogroup O1 El Tor) + H+ + UDP (EC 2.4.1.182)
ABIE51_RS06880
Tetraacyldisaccharide 4'-kinase:
lipid A disaccharide (Vibrio cholerae serogroup O1 El Tor) + ATP→lipid IVA (Vibrio cholerae serogroup O1 El Tor) + ADP + H+ (EC 2.7.1.130)
ABIE51_RS12470

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information