MetaCyc Pathway: representative whole plasma arachidonate-derived icosanoids I in Lysobacter sp. OAE881

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15-hydroxyicosatetraenoate dehydrogenase:
15(S)-HETE + NAD(P)+→15-oxo-ETE + NAD(P)H + H+ (EC 1.1.1.232)
No genes
1-acylglycerophosphocholine O-acyltransferase:
a 2-lysophosphatidylcholine + an acyl-CoA→a phosphatidylcholine + coenzyme A (EC 2.3.1.23)
ABIE51_RS00205
ABIE51_RS01495
Arachidonate 12-lipoxygenase:
arachidonate + dioxygen→(12S)-HpETE (EC 1.13.11.31)
No genes
Arachidonate 15-lipoxygenase:
arachidonate + dioxygen→(15S)-HpETE (EC 1.13.11.33)
No genes
Arachidonate 5-lipoxygenase:
arachidonate + dioxygen→(5S)-HpETE (EC 1.13.11.34)
No genes
Arachidonate 8-lipoxygenase:
arachidonate + dioxygen→(8S)-HpETE (EC 1.13.11.40)
No genes
Phospholipid-hydroperoxide glutathione peroxidase:
(12S)-HpETE + 2 glutathione→12(S)-HETE + glutathione disulfide + H2O (EC 1.11.1.12)
No genes
Phospholipid-hydroperoxide glutathione peroxidase:
(5S)-HpETE + 2 glutathione→5(S)-HETE + glutathione disulfide + H2O (EC 1.11.1.12)
No genes
5(S)-HETE + NADP+→5-oxo-ETE + NADPH + H+ (EC 1.1.1.M76)
No genes
12(S)-HETE + NADP+→12-oxo-ETE + NADPH + H+
No genes
Phospholipid-hydroperoxide glutathione peroxidase:
(8S)-HpETE + 2 glutathione→8(S)-HETE + glutathione disulfide + H2O (EC 1.11.1.12)
No genes
Phospholipase A(2):
a 1-acyl-2-arachidonoyl-phosphatidylcholine + H2O→a 2-lysophosphatidylcholine + arachidonate + H+ (EC 3.1.1.4)
No genes
Phospholipid-hydroperoxide glutathione peroxidase:
(15S)-HpETE + 2 glutathione→15(S)-HETE + glutathione disulfide + H2O (EC 1.11.1.12)
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information