MetaCyc Pathway: flavin biosynthesis I (bacteria and plants) in Klebsiella michiganensis M5al

Add experiment(s):


3,4-dihydroxy-2-butanone-4-phosphate synthase:
D-ribulose 5-phosphate→1-deoxy-L-glycero-tetrulose 4-phosphate + formate + H+ (EC 4.1.99.12)
BWI76_RS11945
BWI76_RS24440
GTP cyclohydrolase II:
GTP + 4 H2O→2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + formate + 3 H+ + 2 phosphate (EC 3.5.4.25)
BWI76_RS11945
Diaminohydroxyphosphoribosylaminopyrimidine deaminase:
2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + H+ + H2O→5-amino-6-(5-phospho-D-ribosylamino)uracil + ammonium (EC 3.5.4.26)
BWI76_RS06350
5-amino-6-(5-phosphoribosylamino)uracil reductase (in reverse):
5-amino-6-(5-phospho-D-ribosylamino)uracil + NADPH + H+→5-amino-6-(5-phospho-D-ribitylamino)uracil + NADP+ (EC 1.1.1.193)
BWI76_RS06350
5-amino-6-(5-phospho-D-ribitylamino)uracil + H2O→5-amino-6-(D-ribitylamino)uracil + phosphate (EC 3.1.3.104)
BWI76_RS01215
BWI76_RS09165
5-amino-6-(D-ribitylamino)uracil + 1-deoxy-L-glycero-tetrulose 4-phosphate→6,7-dimethyl-8-(1-D-ribityl)lumazine + H+ + phosphate + 2 H2O (EC 2.5.1.78)
BWI76_RS06355
Riboflavin synthase:
2 6,7-dimethyl-8-(1-D-ribityl)lumazine + H+→5-amino-6-(D-ribitylamino)uracil + riboflavin (EC 2.5.1.9)
BWI76_RS16530
Riboflavin kinase:
riboflavin + ATP→FMN + ADP + H+ (EC 2.7.1.26)
BWI76_RS04335
FAD synthetase:
FMN + ATP + H+→FAD + diphosphate (EC 2.7.7.2)
BWI76_RS04335

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information