MetaCyc Pathway: superpathway of fermentation (<i>Chlamydomonas reinhardtii</i>) in Klebsiella michiganensis M5al

MetaCyc Pathway: superpathway of fermentation (Chlamydomonas reinhardtii) in Klebsiella michiganensis M5al

Formate C-acetyltransferase (in reverse):
pyruvate + coenzyme A→acetyl-CoA + formate (EC 2.3.1.54)

Pyruvate decarboxylase:
pyruvate + H⁺→acetaldehyde + CO₂ (EC 4.1.1.1)

Acetaldehyde dehydrogenase (acetylating) (in reverse):
acetyl-CoA + NADH + H⁺→acetaldehyde + coenzyme A + NAD⁺ (EC 1.2.1.10)

Pyruvate synthase:
pyruvate + coenzyme A + 2 an oxidized ferredoxin [iron-sulfur] cluster→acetyl-CoA + CO₂ + H⁺ + 2 a reduced ferredoxin [iron-sulfur] cluster (EC 1.2.7.1)

Alcohol dehydrogenase (in reverse):
acetaldehyde + NADH + H⁺→ethanol + NAD⁺ (EC 1.1.1.1)

D-lactate dehydrogenase (in reverse):
pyruvate + NADH + H⁺→(R)-lactate + NAD⁺ (EC 1.1.1.28)

Ferredoxin hydrogenase (in reverse):
2 a reduced ferredoxin [iron-sulfur] cluster + 2 H⁺→H₂ + 2 an oxidized ferredoxin [iron-sulfur] cluster (EC 1.12.7.2)

Phosphate acetyltransferase:
acetyl-CoA + phosphate→acetyl phosphate + coenzyme A (EC 2.3.1.8)

Acetate kinase (in reverse):
acetyl phosphate + ADP→acetate + ATP (EC 2.7.2.1; 2.7.2.15)

Links:

Pathway details at MetaCyc
Fitness data for 42 genes
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All MetaCyc pathways for Klebsiella michiganensis M5al

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information