MetaCyc Pathway: L-cysteine biosynthesis VI (reverse transsulfuration) in Klebsiella michiganensis M5al

Add experiment(s):


Methionine adenosyltransferase:
L-methionine + ATP + H2O→S-adenosyl-L-methionine + diphosphate + phosphate (EC 2.5.1.6)
BWI76_RS24050
Serine O-acetyltransferase:
L-serine + acetyl-CoA→O-acetyl-L-serine + coenzyme A (EC 2.3.1.30)
BWI76_RS05560
BWI76_RS27205
S-adenosyl-L-methionine + a demethylated methyl acceptor→S-adenosyl-L-homocysteine + a methylated methyl acceptor + H+
No genes
Adenosylhomocysteine nucleosidase:
S-adenosyl-L-homocysteine + H2O→S-ribosyl-L-homocysteine + adenine (EC 3.2.2.9)
BWI76_RS05170
S-ribosylhomocysteine lyase:
S-ribosyl-L-homocysteine→L-homocysteine + autoinducer 2 (EC 4.4.1.21)
BWI76_RS22115
O-acetyl-L-serine + L-homocysteine→L-cystathionine + acetate + H+ (EC 2.5.1.134)
No genes
Cystathionine gamma-lyase:
L-cystathionine + H2O→L-cysteine + 2-oxobutanoate + ammonium (EC 4.4.1.1)
BWI76_RS16730
BWI76_RS24210

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information