MetaCyc Pathway: 2-allylmalonyl-CoA biosynthesis in Klebsiella michiganensis M5al

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propanoyl-CoA + TcsB polyketide synthase→propanoyl-[TcsB polyketide synthase] + coenzyme A
No genes
malonyl-CoA + TcsA polyketide synthase→malonyl-[TcsA polyketide synthase] + coenzyme A
No genes
malonyl-[TcsA polyketide synthase] + propanoyl-[TcsB polyketide synthase] + H+→3-oxopentanoyl-[TcsA polyketide synthase] + CO2 + TcsB polyketide synthase
No genes
3-oxoacyl-[acyl-carrier-protein] reductase (in reverse):
3-oxopentanoyl-[TcsA polyketide synthase] + NADPH + H+→(3R)-3-hydroxypentanoyl-[TcsA polyketide synthase] + NADP+ (EC 1.1.1.100)
BWI76_RS07385
BWI76_RS07645
BWI76_RS08900
BWI76_RS10295
BWI76_RS11090
BWI76_RS14895
BWI76_RS16075
BWI76_RS16590
BWI76_RS22505
BWI76_RS23705
3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase:
(3R)-3-hydroxypentanoyl-[TcsA polyketide synthase]→(2E)-pent-2-enoyl-[TcsA polyketide synthase] + H2O (EC 4.2.1.59)
BWI76_RS05270
BWI76_RS09955
(2E)-pent-2-enoyl-[TcsA polyketide synthase] + CO2 + NADPH→2-carboxypentanoyl-[TcsA polyketide synthase] + NADP+
No genes
2-carboxypentanoyl-[TcsA polyketide synthase] + FAD + H+→2-allylmalonyl-[TcsA polyketide synthase] + FADH2
No genes
2-allylmalonyl-[TcsA polyketide synthase] + coenzyme A→2-allylmalonyl-CoA + TcsA polyketide synthase
No genes

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information