MetaCyc Pathway: 1,3-propanediol biosynthesis (engineered) in Klebsiella michiganensis M5al

Add experiment(s):


D-glucose[out] + H+[out]→D-glucose[in] + H+[in]
BWI76_RS24055
Hexokinase:
D-glucopyranose + ATP→D-glucopyranose 6-phosphate + ADP + H+ (EC 2.7.1.1; 2.7.1.2)
BWI76_RS20510
Glucose-6-phosphate isomerase:
α-D-glucose 6-phosphate→β-D-fructofuranose 6-phosphate (EC 5.3.1.9)
BWI76_RS01800
6-phosphofructokinase:
β-D-fructofuranose 6-phosphate + ATP→β-D-fructofuranose 1,6-bisphosphate + ADP + H+ (EC 2.7.1.11)
BWI76_RS00530
BWI76_RS00735
BWI76_RS17175
Fructose-bisphosphate aldolase:
β-D-fructofuranose 1,6-bisphosphate→glycerone phosphate + D-glyceraldehyde 3-phosphate (EC 4.1.2.13)
BWI76_RS00545
BWI76_RS14880
BWI76_RS19370
BWI76_RS23975
BWI76_RS27560
Glycerol-3-phosphate dehydrogenase (NAD(+)) (in reverse):
glycerone phosphate + NADH + H+→sn-glycerol 3-phosphate + NAD+ (EC 1.1.1.8)
BWI76_RS27210
Glycerol-1-phosphatase:
sn-glycerol 3-phosphate + H2O→glycerol + phosphate (EC 3.1.3.21)
No genes
Glycerol dehydratase:
glycerol→3-hydroxypropanal + H2O (EC 4.2.1.30)
No genes
3-hydroxypropanal + NADPH + H+→1,3-propanediol + NADP+
BWI76_RS24300

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information