MetaCyc Pathway: superpathway of guanosine nucleotides de novo biosynthesis I in Klebsiella michiganensis M5al

IMP dehydrogenase: IMP + NAD+ + H2O→XMP + NADH + H+ (EC 1.1.1.205)

BWI76_RS21030

GMP synthase (glutamine-hydrolyzing): XMP + ATP + L-glutamine + H2O→GMP + AMP + L-glutamate + diphosphate + 2 H+ (EC 6.3.5.2)

BWI76_RS14000

BWI76_RS21025

Guanylate kinase: GMP + ATP→GDP + ADP (EC 2.7.4.8)

BWI76_RS02190

BWI76_RS27420

Nucleoside-diphosphate kinase: GDP + ATP→GTP + ADP (EC 2.7.4.6)

BWI76_RS06840

BWI76_RS21100

Ribonucleoside-diphosphate reductase (in reverse): GDP + a reduced thioredoxin→dGDP + an oxidized thioredoxin + H2O (EC 1.17.4.1)

BWI76_RS19940

BWI76_RS19945

BWI76_RS22050

BWI76_RS22055

BWI76_RS22060

Nucleoside-diphosphate kinase: dGDP + ATP→dGTP + ADP (EC 2.7.4.6)

BWI76_RS06840

BWI76_RS21100

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information