MetaCyc Pathway: superpathway of glucose and xylose degradation in Klebsiella michiganensis M5al

MetaCyc Pathway: superpathway of glucose and xylose degradation in Klebsiella michiganensis M5al

Glucose-6-phosphate dehydrogenase:
D-glucopyranose 6-phosphate + NADP⁺→6-phospho D-glucono-1,5-lactone + NADPH + H⁺ (EC 1.1.1.49)

Xylose isomerase:
α-D-xylopyranose→α-D-xylulofuranose (EC 5.3.1.5)

6-phosphogluconolactonase:
6-phospho D-glucono-1,5-lactone + H₂O→D-gluconate 6-phosphate + H⁺ (EC 3.1.1.31)

Xylulokinase:
D-xylulose + ATP→D-xylulose 5-phosphate + ADP + H⁺ (EC 2.7.1.17)

Phosphogluconate dehydrogenase (decarboxylating):
D-gluconate 6-phosphate + NADP⁺→D-ribulose 5-phosphate + CO₂ + NADPH (EC 1.1.1.44)

Ribose-5-phosphate isomerase (in reverse):
D-ribulose 5-phosphate→D-ribose 5-phosphate (EC 5.3.1.6)

Ribulose-phosphate 3-epimerase:
D-ribulose 5-phosphate→D-xylulose 5-phosphate (EC 5.1.3.1)

Transketolase (in reverse):
D-ribose 5-phosphate + D-xylulose 5-phosphate→D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (EC 2.2.1.1)

Transaldolase:
D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate→D-erythrose 4-phosphate + β-D-fructofuranose 6-phosphate (EC 2.2.1.2)

Transketolase:
D-erythrose 4-phosphate + D-xylulose 5-phosphate→β-D-fructofuranose 6-phosphate + D-glyceraldehyde 3-phosphate (EC 2.2.1.1)

Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating):
D-glyceraldehyde 3-phosphate + NAD⁺ + phosphate→3-phospho-D-glyceroyl phosphate + NADH + H⁺ (EC 1.2.1.12)

Phosphoglycerate kinase (in reverse):
3-phospho-D-glyceroyl phosphate + ADP→3-phospho-D-glycerate + ATP (EC 2.7.2.3)

3-phospho-D-glycerate→2-phospho-D-glycerate (EC 5.4.2.12)

Phosphopyruvate hydratase:
2-phospho-D-glycerate→phosphoenolpyruvate + H₂O (EC 4.2.1.11)

Pyruvate kinase (in reverse):
phosphoenolpyruvate + ADP + H⁺→pyruvate + ATP (EC 2.7.1.40)

D-lactate dehydrogenase (in reverse):
pyruvate + NADH + H⁺→(R)-lactate + NAD⁺ (EC 1.1.1.28)

L-lactate dehydrogenase (in reverse):
pyruvate + NADH + H⁺→(S)-lactate + NAD⁺ (EC 1.1.1.27)

Links:

Pathway details at MetaCyc
Fitness data for 38 genes
Select organism:
All MetaCyc pathways for Klebsiella michiganensis M5al

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information