MetaCyc Pathway: superpathway of L-tyrosine biosynthesis in Klebsiella michiganensis M5al

MetaCyc Pathway: superpathway of L-tyrosine biosynthesis in Klebsiella michiganensis M5al

3-deoxy-7-phosphoheptulonate synthase:
D-erythrose 4-phosphate + phosphoenolpyruvate + H₂O→3-deoxy-D-arabino-heptulosonate 7-phosphate + phosphate (EC 2.5.1.54)

3-dehydroquinate synthase:
3-deoxy-D-arabino-heptulosonate 7-phosphate→3-dehydroquinate + phosphate (EC 4.2.3.4)

3-dehydroquinate dehydratase:
3-dehydroquinate→3-dehydroshikimate + H₂O (EC 4.2.1.10)

Shikimate dehydrogenase (in reverse):
3-dehydroshikimate + NADPH + H⁺→shikimate + NADP⁺ (EC 1.1.1.25)

Shikimate kinase:
shikimate + ATP→shikimate 3-phosphate + ADP + H⁺ (EC 2.7.1.71)

3-phosphoshikimate 1-carboxyvinyltransferase:
shikimate 3-phosphate + phosphoenolpyruvate→5-enolpyruvoyl-shikimate 3-phosphate + phosphate (EC 2.5.1.19)

Chorismate synthase:
5-enolpyruvoyl-shikimate 3-phosphate→chorismate + phosphate (EC 4.2.3.5)

Chorismate mutase:
chorismate→prephenate (EC 5.4.99.5)

Prephenate dehydrogenase:
prephenate + NAD⁺→3-(4-hydroxyphenyl)pyruvate + CO₂ + NADH (EC 1.3.1.12)

Aspartate transaminase (in reverse):
3-(4-hydroxyphenyl)pyruvate + L-glutamate→L-tyrosine + 2-oxoglutarate (EC 2.6.1.1; 2.6.1.27; 2.6.1.5; 2.6.1.57)

Links:

Pathway details at MetaCyc
Fitness data for 33 genes
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All MetaCyc pathways for Klebsiella michiganensis M5al

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information