MetaCyc Pathway: chorismate biosynthesis II (archaea) in Klebsiella michiganensis M5al

Add experiment(s):


Aspartate kinase:
L-aspartate + ATP→L-aspartyl-4-phosphate + ADP (EC 2.7.2.4)
BWI76_RS00790
BWI76_RS01790
BWI76_RS04245
D-glyceraldehyde 3-phosphate→enolaldehyde + phosphate
No genes
Aspartate-semialdehyde dehydrogenase (in reverse):
L-aspartyl-4-phosphate + NADPH + H+→L-aspartate 4-semialdehyde + NADP+ + phosphate (EC 1.2.1.11)
BWI76_RS12880
BWI76_RS20385
BWI76_RS26220
enolaldehyde→methylglyoxal (spontaneous)
No genes
methylglyoxal + β-D-fructofuranose 1,6-bisphosphate→D-glyceraldehyde 3-phosphate + 6-deoxy-5-ketofructose 1-phosphate (EC 2.2.1.11)
No genes
6-deoxy-5-ketofructose 1-phosphate + L-aspartate 4-semialdehyde→2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate + hydroxypyruvaldehyde phosphate (EC 2.2.1.10)
No genes
2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate + NAD+ + H2O→3-dehydroquinate + ammonium + NADH + H+ (EC 1.4.1.24)
No genes
3-dehydroquinate dehydratase:
3-dehydroquinate→3-dehydroshikimate + H2O (EC 4.2.1.10)
BWI76_RS04645
BWI76_RS22790
Shikimate dehydrogenase (in reverse):
3-dehydroshikimate + NADPH + H+→shikimate + NADP+ (EC 1.1.1.25)
BWI76_RS01715
BWI76_RS04655
BWI76_RS06460
BWI76_RS16935
BWI76_RS25645
Shikimate kinase:
shikimate + ATP→shikimate 3-phosphate + ADP + H+ (EC 2.7.1.71)
BWI76_RS06185
BWI76_RS26090
3-phosphoshikimate 1-carboxyvinyltransferase:
shikimate 3-phosphate + phosphoenolpyruvate→5-enolpyruvoyl-shikimate 3-phosphate + phosphate (EC 2.5.1.19)
BWI76_RS09760
Chorismate synthase:
5-enolpyruvoyl-shikimate 3-phosphate→chorismate + phosphate (EC 4.2.3.5)
BWI76_RS20435

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information