MetaCyc Pathway: incomplete reductive TCA cycle in Klebsiella michiganensis M5al

Pyruvate synthase (in reverse): acetyl-CoA + CO2 + H+ + 2 a reduced ferredoxin [iron-sulfur] cluster→pyruvate + coenzyme A + 2 an oxidized ferredoxin [iron-sulfur] cluster (EC 1.2.7.1)

BWI76_RS12730

BWI76_RS18805

Pyruvate carboxylase: pyruvate + ATP + hydrogen carbonate→oxaloacetate + ADP + H+ + phosphate (EC 6.4.1.1)

No genes

Malate dehydrogenase (in reverse): oxaloacetate + NADH + H+→(S)-malate + NAD+ (EC 1.1.1.37; 1.1.1.38)

BWI76_RS13830

BWI76_RS16775

BWI76_RS25420

Fumarate hydratase: (S)-malate→fumarate + H2O (EC 4.2.1.2)

BWI76_RS08450

BWI76_RS16115

BWI76_RS16270

BWI76_RS16275

BWI76_RS16955

Succinate dehydrogenase (ubiquinone): fumarate[in] + a menaquinol→succinate[in] + a menaquinone (EC 1.3.5.1)

BWI76_RS02440

BWI76_RS02445

BWI76_RS02450

BWI76_RS02455

Succinate--CoA ligase (ADP-forming): succinate + ATP + coenzyme A→succinyl-CoA + ADP + phosphate (EC 6.2.1.5)

BWI76_RS08425

BWI76_RS08430

2-oxoglutarate synthase (in reverse): succinyl-CoA + CO2 + H+ + 2 a reduced ferredoxin [iron-sulfur] cluster→2-oxoglutarate + coenzyme A + 2 an oxidized ferredoxin [iron-sulfur] cluster (EC 1.2.7.3)

No genes

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information