MetaCyc Pathway: TCA cycle IV (2-oxoglutarate decarboxylase) in Klebsiella michiganensis M5al

Add experiment(s):


Aconitate hydratase:
citrate→cis-aconitate + H2O (EC 4.2.1.3)
BWI76_RS04910
BWI76_RS11940
Aconitate hydratase:
cis-aconitate + H2O→D-threo-isocitrate (EC 4.2.1.3)
BWI76_RS04910
BWI76_RS11940
Isocitrate dehydrogenase (NADP(+)):
D-threo-isocitrate + NADP+→2-oxoglutarate + CO2 + NADPH (EC 1.1.1.42)
BWI76_RS11330
2-oxoglutarate decarboxylase:
2-oxoglutarate + H+→succinate semialdehyde + CO2 (EC 4.1.1.71)
No genes
succinate semialdehyde + NADP+ + H2O→succinate + NADPH + 2 H+ (EC 1.2.1.79)
BWI76_RS05620
Succinate dehydrogenase (ubiquinone):
succinate[in] + an electron-transfer quinone→fumarate[in] + an electron-transfer quinol (EC 1.3.5.1)
No genes
Fumarate hydratase (in reverse):
fumarate + H2O→(S)-malate (EC 4.2.1.2)
BWI76_RS08450
BWI76_RS16115
BWI76_RS16270
BWI76_RS16275
BWI76_RS16955
Malate dehydrogenase:
(S)-malate + NAD+→oxaloacetate + NADH + H+ (EC 1.1.1.37; 1.1.1.38)
BWI76_RS13830
BWI76_RS16775
BWI76_RS25420
Citrate (Si)-synthase:
oxaloacetate + acetyl-CoA + H2O→citrate + coenzyme A + H+ (EC 2.3.3.1; 2.3.3.16; 2.3.3.3)
BWI76_RS08385
BWI76_RS19140

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information