Phospholipase A(2):
a [glycerolipid]-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + H2O→(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + a glycerolipid + H+ (EC 3.1.1.4) |
| No genes |
Arachidonate 5-lipoxygenase:
(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + dioxygen→(7S)-HpDHA (EC 1.13.11.34) |
| No genes |
Arachidonate 12-lipoxygenase:
(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + dioxygen→(14S)-HpDHA (EC 1.13.11.31) |
| No genes |
| (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + a reduced two electron carrier + dioxygen + H+→13-HDoHE + an oxidized electron carrier + H2O |
| No genes |
| (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + dioxygen + a reduced [NADPH-hemoprotein reductase]→16(17)-EpDPE + an oxidized [NADPH-hemoprotein reductase] + H2O |
| No genes |
Arachidonate 5-lipoxygenase:
(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + dioxygen→(4S)-HpDHA (EC 1.13.11.34) |
| No genes |
Arachidonate 12-lipoxygenase:
(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + dioxygen→(11S)-HpDHA (EC 1.13.11.31) |
| No genes |
| (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + a reduced two electron carrier + dioxygen→10-HDoHE + an oxidized electron carrier + H2O (spontaneous) |
| No genes |
| (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + a reduced two electron carrier + dioxygen→20-HDoHE + an oxidized electron carrier + H2O (spontaneous) |
| No genes |
| (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + a reduced two electron carrier + dioxygen→17(R)-HDoHE + an oxidized electron carrier + H2O |
| No genes |
Arachidonate 15-lipoxygenase:
(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + dioxygen→(17S)-HpDHA (EC 1.13.11.33) |
| MPMX20_04771 |
| (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + dioxygen + a reduced [NADPH-hemoprotein reductase]→19(20)-EpDPE + an oxidized [NADPH-hemoprotein reductase] + H2O |
| No genes |
Phospholipid-hydroperoxide glutathione peroxidase:
(17S)-HpDHA + 2 glutathione→17(S)-HDoHE + glutathione disulfide + H2O (EC 1.11.1.12) |
| No genes |
Arachidonate 15-lipoxygenase:
(17S)-HpDHA→(16S,17S)-epoxy-protectin + H2O (EC 1.13.11.33) |
| MPMX20_04771 |
Arachidonate 12-lipoxygenase:
(14S)-HpDHA→(13S,14S)-epoxy-maresin + H2O (EC 1.13.11.31) |
| No genes |
Phospholipid-hydroperoxide glutathione peroxidase:
(14S)-HpDHA + 2 glutathione + H+→glutathione disulfide + (14S)-HDoHE + H2O (EC 1.11.1.12) |
| No genes |
Arachidonate 15-lipoxygenase:
(17S)-HpDHA + dioxygen→(10S,17S)-diHpDHA (EC 1.13.11.33) |
| MPMX20_04771 |
Soluble epoxide hydrolase:
19(20)-EpDPE + H2O→19,20-DiHDPE (EC 3.3.2.10) |
| No genes |
Phospholipid-hydroperoxide glutathione peroxidase:
(4S)-HpDHA + 2 glutathione→glutathione disulfide + 4S-HDoHE + H2O (EC 1.11.1.12) |
| No genes |
Phospholipid-hydroperoxide glutathione peroxidase:
(7S)-HpDHA + 2 glutathione→glutathione disulfide + 7S-HDoHE + H2O (EC 1.11.1.12) |
| No genes |
Phospholipid-hydroperoxide glutathione peroxidase:
(11S)-HpDHA + 2 glutathione→glutathione disulfide + 11S-HDoHE + H2O (EC 1.11.1.12) |
| No genes |
Arachidonate 5-lipoxygenase:
17(R)-HDoHE + dioxygen→(7S,17R)-17-hydroxy-7-hydroperoxydocosahexaenoate (EC 1.13.11.34) |
| No genes |
Soluble epoxide hydrolase:
(13S,14S)-epoxy-maresin + H2O→maresin 1 (EC 3.3.2.10) |
| No genes |
| (16S,17S)-epoxy-protectin + H2O→protectin D1 |
| No genes |
Phospholipid-hydroperoxide glutathione peroxidase:
(10S,17S)-diHpDHA + 4 glutathione→2 glutathione disulfide + protectin DX + 2 H2O (EC 1.11.1.12) |
| No genes |
Arachidonate 5-lipoxygenase:
(7S,17R)-17-hydroxy-7-hydroperoxydocosahexaenoate→7(8)-epoxy-17R-hydroxy-docosahexaenoate + H2O (EC 1.13.11.34) |
| No genes |
Arachidonate 5-lipoxygenase:
17(S)-HDoHE + dioxygen→(7S,17S)-17-hydroxy-7-hydroperoxydocosahexaenoate (EC 1.13.11.34) |
| No genes |
| 7(8)-epoxy-17R-hydroxy-docosahexaenoate + H2O→aspirin triggered resolvin D2 |
| No genes |
Arachidonate 5-lipoxygenase:
(7S,17S)-17-hydroxy-7-hydroperoxydocosahexaenoate→(7S,8S)-epoxy-resolvin + H2O (EC 1.13.11.34) |
| No genes |
| (7S,8S)-epoxy-resolvin + H2O→resolvin D1 |
| No genes |
| (7S,8S)-epoxy-resolvin + H2O→resolvin D2 |
| No genes |
Links:
Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information