MetaCyc Pathway: adipate degradation in Enterobacter sp. TBS

MetaCyc Pathway: adipate degradation in Enterobacter sp. TBS_079

Succinate--CoA ligase (ADP-forming):
adipate + ATP + coenzyme A→adipoyl-CoA + ADP + phosphate (EC 6.2.1.5)

adipoyl-CoA + an oxidized electron-transfer flavoprotein + H⁺→(2E)-5-carboxy-2-pentenoyl-CoA + a reduced electron-transfer flavoprotein (EC 1.3.8.7)

MPMX20_00463

Enoyl-CoA hydratase (in reverse):
(2E)-5-carboxy-2-pentenoyl-CoA + H₂O→(3S)-hydroxyadipyl-CoA (EC 4.2.1.17)

3-hydroxyacyl-CoA dehydrogenase:
(3S)-hydroxyadipyl-CoA + NAD⁺→3-oxoadipoyl-CoA + NADH + H⁺ (EC 1.1.1.35)

MPMX20_02149

MPMX20_03268

MPMX20_04436

3-oxoadipyl-CoA thiolase (in reverse):
3-oxoadipoyl-CoA + coenzyme A→succinyl-CoA + acetyl-CoA (EC 2.3.1.174)

MPMX20_02151

Links:

Pathway details at MetaCyc
Fitness data for 10 genes
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All MetaCyc pathways for Enterobacter sp. TBS_079

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information